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Page 1
Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis.
Ramón-García S, Del Río RG, Arenaz-Callao MP, Boshoff H, Rullás J, Anca S, Izquierdo MC, de Francisco EP, Herrán EP, Santos-Villarejo A, Mendoza-Losana A, Ferrer-Bazaga S, Thompson CJ, Aguirre DB, Bates RH. Ramón-García S, et al. Among authors: mendoza losana a. bioRxiv [Preprint]. 2024 Oct 10:2024.10.10.617558. doi: 10.1101/2024.10.10.617558. bioRxiv. 2024. PMID: 39803560 Free PMC article. Preprint.
Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis.
Encinas L, Li S-Y, Rullas-Trincado J, Tasneen R, Tyagi S, Soni H, Garcia-Perez A, Lee J, González Del Río R, De Mercado J, Sousa V, Sosič I, Gobec S, Mendoza-Losana A, Converse PJ, Mdluli K, Fotouhi N, Barros-Aguirre D, Nuermberger EL. Encinas L, et al. Among authors: mendoza losana a. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0035724. doi: 10.1128/aac.00357-24. Epub 2024 Sep 30. Antimicrob Agents Chemother. 2024. PMID: 39345183 Free PMC article.
Plasmodium RNA triphosphatase validation as antimalarial target.
Moliner-Cubel S, Bahamontes-Rosa N, Rodriguez-Alejandre A, Nassau PM, Argyrou A, Bhardwaja A, Buxton RC, Calvo-Vicente D, Mouzon B, McDowell W, Mendoza-Losana A, Gomez-Lorenzo MG. Moliner-Cubel S, et al. Among authors: mendoza losana a. Int J Parasitol Drugs Drug Resist. 2024 Aug;25:100537. doi: 10.1016/j.ijpddr.2024.100537. Epub 2024 Apr 26. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38810336 Free PMC article.
Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes.
Huang W, Rodrigues J, Bilgo E, Tormo JR, Challenger JD, De Cozar-Gallardo C, Pérez-Victoria I, Reyes F, Castañeda-Casado P, Gnambani EJ, Hien DFS, Konkobo M, Urones B, Coppens I, Mendoza-Losana A, Ballell L, Diabate A, Churcher TS, Jacobs-Lorena M. Huang W, et al. Among authors: mendoza losana a. Science. 2023 Aug 4;381(6657):533-540. doi: 10.1126/science.adf8141. Epub 2023 Aug 3. Science. 2023. PMID: 37535741
Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis.
Tsui CKM, Sorrentino F, Narula G, Mendoza-Losana A, Del Rio RG, Herrán EP, Lopez A, Bojang A, Zheng X, Remuiñán-Blanco MJ, Av-Gay Y. Tsui CKM, et al. Among authors: mendoza losana a. Molecules. 2022 Jul 12;27(14):4446. doi: 10.3390/molecules27144446. Molecules. 2022. PMID: 35889319 Free PMC article.
Comparison of 8 weeks standard treatment (rifampicin plus clarithromycin) vs. 4 weeks standard plus amoxicillin/clavulanate treatment [RC8 vs. RCA4] to shorten Buruli ulcer disease therapy (the BLMs4BU trial): study protocol for a randomized controlled multi-centre trial in Benin.
Johnson RC, Sáez-López E, Anagonou ES, Kpoton GG, Ayelo AG, Gnimavo RS, Mignanwande FZ, Houezo JG, Sopoh GE, Addo J, Orford L, Vlasakakis G, Biswas N, Calderon F, Della Pasqua O, Gine-March A, Herrador Z, Mendoza-Losana A, Díez G, Cruz I, Ramón-García S. Johnson RC, et al. Among authors: mendoza losana a. Trials. 2022 Jul 8;23(1):559. doi: 10.1186/s13063-022-06473-9. Trials. 2022. PMID: 35804454 Free PMC article.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Flipo M, Frita R, Bourotte M, Martínez-Martínez MS, Boesche M, Boyle GW, Derimanov G, Drewes G, Gamallo P, Ghidelli-Disse S, Gresham S, Jiménez E, de Mercado J, Pérez-Herrán E, Porras-De Francisco E, Rullas J, Casado P, Leroux F, Piveteau C, Kiass M, Mathys V, Soetaert K, Megalizzi V, Tanina A, Wintjens R, Antoine R, Brodin P, Delorme V, Moune M, Djaout K, Slupek S, Kemmer C, Gitzinger M, Ballell L, Mendoza-Losana A, Lociuro S, Deprez B, Barros-Aguirre D, Remuiñán MJ, Willand N, Baulard AR. Flipo M, et al. Among authors: mendoza losana a. Sci Transl Med. 2022 May 4;14(643):eaaz6280. doi: 10.1126/scitranslmed.aaz6280. Epub 2022 May 4. Sci Transl Med. 2022. PMID: 35507672
Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis.
Grover S, Engelhart CA, Pérez-Herrán E, Li W, Abrahams KA, Papavinasasundaram K, Bean JM, Sassetti CM, Mendoza-Losana A, Besra GS, Jackson M, Schnappinger D. Grover S, et al. Among authors: mendoza losana a. ACS Infect Dis. 2021 Jan 8;7(1):141-152. doi: 10.1021/acsinfecdis.0c00675. Epub 2020 Dec 15. ACS Infect Dis. 2021. PMID: 33319550 Free PMC article.
Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.
Lopez Quezada L, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K, Somersan Karakaya S, Javidnia PE, Porras de Francisco E, Amieva MM, Dı Az SP, Mendoza Losana A, Zimmerman M, Liang HH, Zhang J, Dartois V, Sans S, Lagrange S, Goullieux L, Roubert C, Nathan C, Aubé J. Lopez Quezada L, et al. Among authors: mendoza losana a. ACS Infect Dis. 2019 Aug 9;5(8):1433-1445. doi: 10.1021/acsinfecdis.9b00112. Epub 2019 Jun 11. ACS Infect Dis. 2019. PMID: 31184461 Free PMC article.
First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment.
Tenero D, Derimanov G, Carlton A, Tonkyn J, Davies M, Cozens S, Gresham S, Gaudion A, Puri A, Muliaditan M, Rullas-Trincado J, Mendoza-Losana A, Skingsley A, Barros-Aguirre D. Tenero D, et al. Among authors: mendoza losana a. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00240-19. doi: 10.1128/AAC.00240-19. Print 2019 Aug. Antimicrob Agents Chemother. 2019. PMID: 31182528 Free PMC article. Clinical Trial.
33 results