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Page 1
Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification.
Trotta AM, Mazzarella V, Roggia M, D'Aniello A, Del Bene A, Vetrei C, Di Maiolo G, Campagna E, Natale B, Rea G, Santagata S, D'Alterio C, Cutolo R, Mottola S, Merlino F, Benedetti R, Altucci L, Messere A, Cosconati S, Tomassi S, Scala S, Di Maro S. Trotta AM, et al. Eur J Med Chem. 2024 Dec 5;279:116911. doi: 10.1016/j.ejmech.2024.116911. Epub 2024 Sep 25. Eur J Med Chem. 2024. PMID: 39348763
Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists.
Di Maro S, Trotta AM, Brancaccio D, Di Leva FS, La Pietra V, Ieranò C, Napolitano M, Portella L, D'Alterio C, Siciliano RA, Sementa D, Tomassi S, Carotenuto A, Novellino E, Scala S, Marinelli L. Di Maro S, et al. Among authors: trotta am. J Med Chem. 2016 Sep 22;59(18):8369-80. doi: 10.1021/acs.jmedchem.6b00695. Epub 2016 Sep 9. J Med Chem. 2016. PMID: 27571038
Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist.
Di Maro S, Di Leva FS, Trotta AM, Brancaccio D, Portella L, Aurilio M, Tomassi S, Messere A, Sementa D, Lastoria S, Carotenuto A, Novellino E, Scala S, Marinelli L. Di Maro S, et al. Among authors: trotta am. J Med Chem. 2017 Dec 14;60(23):9641-9652. doi: 10.1021/acs.jmedchem.7b01062. Epub 2017 Nov 20. J Med Chem. 2017. PMID: 29125295
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites.
Trotta AM, Tomassi S, Di Maiolo G, Ieranò C, Vetrei C, D'Alterio C, Merlino F, Messere A, D'Aniello A, Del Bene A, Mazzarella V, Roggia M, Natale B, Cutolo R, Campagna E, Mottola S, Russo R, Chambery A, Benedetti R, Altucci L, Cosconati S, Scala S, Di Maro S. Trotta AM, et al. Eur J Med Chem. 2024 Oct 5;276:116669. doi: 10.1016/j.ejmech.2024.116669. Epub 2024 Jul 14. Eur J Med Chem. 2024. PMID: 39053189
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences.
Tomassi S, Trotta AM, Ieranò C, Merlino F, Messere A, Rea G, Santoro F, Brancaccio D, Carotenuto A, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Marinelli L, Scala S, Di Maro S. Tomassi S, et al. Among authors: trotta am. Chemistry. 2020 Aug 6;26(44):10113-10125. doi: 10.1002/chem.202002468. Epub 2020 Jul 20. Chemistry. 2020. PMID: 32603023
Novel Peptide-Based PET Probe for Non-invasive Imaging of C-X-C Chemokine Receptor Type 4 (CXCR4) in Tumors.
Trotta AM, Aurilio M, D'Alterio C, Ieranò C, Di Martino D, Barbieri A, Luciano A, Gaballo P, Santagata S, Portella L, Tomassi S, Marinelli L, Sementa D, Novellino E, Lastoria S, Scala S, Schottelius M, Di Maro S. Trotta AM, et al. J Med Chem. 2021 Mar 25;64(6):3449-3461. doi: 10.1021/acs.jmedchem.1c00066. Epub 2021 Mar 4. J Med Chem. 2021. PMID: 33660512
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients.
Santagata S, Rea G, Bello AM, Capiluongo A, Napolitano M, Desicato S, Fragale A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Persico F, Di Napoli M, Di Maro S, Feroce F, Azzaro R, Gabriele L, Longo N, Pignata S, Perdonà S, Scala S. Santagata S, et al. Among authors: trotta am. Br J Cancer. 2024 Jun;130(12):2016-2026. doi: 10.1038/s41416-024-02702-x. Epub 2024 May 4. Br J Cancer. 2024. PMID: 38704478 Free PMC article.
New CXCR4 Antagonist Peptide R (Pep R) Improves Standard Therapy in Colorectal Cancer.
D'Alterio C, Zannetti A, Trotta AM, Ieranò C, Napolitano M, Rea G, Greco A, Maiolino P, Albanese S, Scognamiglio G, Tatangelo F, Tafuto S, Portella L, Santagata S, Nasti G, Ottaiano A, Pacelli R, Delrio P, Botti G, Scala S. D'Alterio C, et al. Among authors: trotta am. Cancers (Basel). 2020 Jul 18;12(7):1952. doi: 10.3390/cancers12071952. Cancers (Basel). 2020. PMID: 32708431 Free PMC article.
35 results