Sekiguchi M - Search Results

1

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Iwata N, Tsubuki S, Sekiguchi M, Watanabe-Iwata K, Matsuba Y, Kamano N, Fujioka R, Takamura R, Watamura N, Kakiya N, Mihira N, Morito T, Shirotani K, Mann DM, Robinson AC, Hashimoto S, Sasaguri H, Saito T, Higuchi M, Saido TC. Iwata N, et al. Among authors: sekiguchi m. Life Sci Alliance. 2024 Sep 30;7(12):e202402650. doi: 10.26508/lsa.202402650. Print 2024 Dec. Life Sci Alliance. 2024. PMID: 39348937 Free PMC article.

2

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.

Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC. Iwata N, et al. Among authors: sekiguchi m. Nat Med. 2000 Feb;6(2):143-50. doi: 10.1038/72237. Nat Med. 2000. PMID: 10655101

3

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.

Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC. Iwata N, et al. Among authors: sekiguchi m. Sci Rep. 2013;3:1472. doi: 10.1038/srep01472. Sci Rep. 2013. PMID: 23503602 Free PMC article.

4

Aβ secretion and plaque formation depend on autophagy.

Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC. Nilsson P, et al. Among authors: sekiguchi m. Cell Rep. 2013 Oct 17;5(1):61-9. doi: 10.1016/j.celrep.2013.08.042. Epub 2013 Oct 3. Cell Rep. 2013. PMID: 24095740 Free article.

5

Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC. Nilsson P, et al. Among authors: sekiguchi m. Am J Pathol. 2015 Feb;185(2):305-13. doi: 10.1016/j.ajpath.2014.10.011. Epub 2014 Nov 26. Am J Pathol. 2015. PMID: 25433221 Free article.

6

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Nilsson P, Loganathan K, Sekiguchi M, Winblad B, Iwata N, Saido TC, Tjernberg LO. Nilsson P, et al. Among authors: sekiguchi m. Proteomics. 2015 Oct;15(19):3349-55. doi: 10.1002/pmic.201400211. Epub 2015 Aug 13. Proteomics. 2015. PMID: 26194619

7

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Sasaguri H, et al. Among authors: sekiguchi m. Nat Commun. 2018 Jul 24;9(1):2892. doi: 10.1038/s41467-018-05262-w. Nat Commun. 2018. PMID: 30042426 Free PMC article.

8

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.

Schedin-Weiss S, Nilsson P, Sandebring-Matton A, Axenhus M, Sekiguchi M, Saito T, Winblad B, Saido T, Tjernberg LO. Schedin-Weiss S, et al. Among authors: sekiguchi m. J Alzheimers Dis. 2020;75(1):321-335. doi: 10.3233/JAD-200028. J Alzheimers Dis. 2020. PMID: 32280097 Free PMC article.

9

A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.

Sato K, Watamura N, Fujioka R, Mihira N, Sekiguchi M, Nagata K, Ohshima T, Saito T, Saido TC, Sasaguri H. Sato K, et al. Among authors: sekiguchi m. J Biol Chem. 2021 Sep;297(3):101004. doi: 10.1016/j.jbc.2021.101004. Epub 2021 Jul 27. J Biol Chem. 2021. PMID: 34329683 Free PMC article.

10

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Watamura N, Sato K, Shiihashi G, Iwasaki A, Kamano N, Takahashi M, Sekiguchi M, Mihira N, Fujioka R, Nagata K, Hashimoto S, Saito T, Ohshima T, Saido TC, Sasaguri H. Watamura N, et al. Among authors: sekiguchi m. Sci Adv. 2022 Jun 10;8(23):eabm6155. doi: 10.1126/sciadv.abm6155. Epub 2022 Jun 8. Sci Adv. 2022. PMID: 35675411 Free PMC article.

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