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SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer.
Montero-Hidalgo AJ, Jiménez-Vacas JM, Gómez-Gómez E, Porcel-Pastrana F, Sáez-Martínez P, Pérez-Gómez JM, Fuentes-Fayos AC, Blázquez-Encinas R, Sánchez-Sánchez R, González-Serrano T, Castro E, López-Soto PJ, Carrasco-Valiente J, Sarmento-Cabral A, Martinez-Fuentes AJ, Eyras E, Castaño JP, Sharp A, Olmos D, Gahete MD, Luque RM. Montero-Hidalgo AJ, et al. Among authors: sharp a. Sci Adv. 2024 Oct 4;10(40):eado8231. doi: 10.1126/sciadv.ado8231. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356765 Free PMC article.
Alternative splicing in prostate cancer.
Paschalis A, Sharp A, Welti JC, Neeb A, Raj GV, Luo J, Plymate SR, de Bono JS. Paschalis A, et al. Among authors: sharp a. Nat Rev Clin Oncol. 2018 Nov;15(11):663-675. doi: 10.1038/s41571-018-0085-0. Nat Rev Clin Oncol. 2018. PMID: 30135575 Review.
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer.
Paschalis A, Welti J, Neeb AJ, Yuan W, Figueiredo I, Pereira R, Ferreira A, Riisnaes R, Rodrigues DN, Jiménez-Vacas JM, Kim S, Uo T, Micco PD, Tumber A, Islam MS, Moesser MA, Abboud M, Kawamura A, Gurel B, Christova R, Gil VS, Buroni L, Crespo M, Miranda S, Lambros MB, Carreira S, Tunariu N, Alimonti A, Al-Lazikani B, Schofield CJ, Plymate SR, Sharp A, de Bono JS; , SU2C/PCF International Prostate Cancer Dream Team. Paschalis A, et al. Among authors: sharp a. Cancer Res. 2021 Feb 15;81(4):1087-1100. doi: 10.1158/0008-5472.CAN-20-1807. Cancer Res. 2021. PMID: 33822745 Free PMC article.
Value of Early Circulating Tumor Cells Dynamics to Estimate Docetaxel Benefit in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients.
Lozano R, Lorente D, Aragon IM, Romero-Laorden N, Nombela P, Mateo J, Reid AHM, Cendón Y, Bianchini D, Llacer C, Sandhu SK, Sharp A, Rescigno P, Garcés T, Pacheco MI, Flohr P, Massard C, López-Casas PP, Castro E, de Bono JS, Olmos D. Lozano R, et al. Among authors: sharp a. Cancers (Basel). 2021 May 12;13(10):2334. doi: 10.3390/cancers13102334. Cancers (Basel). 2021. PMID: 34066080 Free PMC article.
A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer.
Westaby D, Fenor de La Maza MLD, Paschalis A, Jimenez-Vacas JM, Welti J, de Bono J, Sharp A. Westaby D, et al. Among authors: sharp a. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:131-153. doi: 10.1146/annurev-pharmtox-052220-015912. Epub 2021 Aug 24. Annu Rev Pharmacol Toxicol. 2022. PMID: 34449248 Review.
Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer.
Sheehan B, Neeb A, Buroni L, Paschalis A, Riisnaes R, Gurel B, Gil V, Miranda S, Crespo M, Guo C, Jiménez Vacas J, Figueiredo I, Ferreira A, Welti J, Yuan W, Carreira S, Sharp A, de Bono J. Sheehan B, et al. Among authors: sharp a. Clin Cancer Res. 2022 Jul 15;28(14):3104-3115. doi: 10.1158/1078-0432.CCR-21-4531. Clin Cancer Res. 2022. PMID: 35552383 Free PMC article.
Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer.
Sowalsky AG, Figueiredo I, Lis RT, Coleman I, Gurel B, Bogdan D, Yuan W, Russo JW, Bright JR, Whitlock NC, Trostel SY, Ku AT, Patel RA, True LD, Welti J, Jimenez-Vacas JM, Rodrigues DN, Riisnaes R, Neeb A, Sprenger CT, Swain A, Wilkinson S, Karzai F, Dahut WL, Balk SP, Corey E, Nelson PS, Haffner MC, Plymate SR, de Bono JS, Sharp A. Sowalsky AG, et al. Among authors: sharp a. Clin Cancer Res. 2022 Aug 15;28(16):3509-3525. doi: 10.1158/1078-0432.CCR-22-0851. Clin Cancer Res. 2022. PMID: 35695870 Free PMC article.
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer.
Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith G, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono JS, Gaughan L. Adamson B, et al. Among authors: sharp a. J Clin Invest. 2023 Nov 15;133(22):e169200. doi: 10.1172/JCI169200. J Clin Invest. 2023. PMID: 37751307 Free PMC article.
1,115 results