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Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.
Pfannenstiel JJ, Duong MTH, Cluff D, Sherrill LM, Colquhoun I, Cadoux G, Thorne D, Pääkkönen J, Schemmel NF, O'Connor J, Saenjamsai P, Feng M, Hageman MJ, Johnson DK, Roy A, Lehtiö L, Ferraris DV, Fehr AR. Pfannenstiel JJ, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2024 Oct 29:2024.10.28.620664. doi: 10.1101/2024.10.28.620664. bioRxiv. 2024. PMID: 39554145 Free PMC article. Preprint.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: fehr ar. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
Molecular and functional landscape of malignant serous effusions for precision oncology.
Wegmann R, Bankel L, Festl Y, Lau K, Lee S, Arnold F, Cappelletti V, Fehr A, Picotti P, Dedes KJ, Franzen D, Lenggenhager D, Bode PK, Zoche M, Moch H, Britschgi C, Snijder B. Wegmann R, et al. Among authors: fehr a. Nat Commun. 2024 Oct 2;15(1):8544. doi: 10.1038/s41467-024-52694-8. Nat Commun. 2024. PMID: 39358333 Free PMC article.
Socioeconomic disparities in changes to preterm birth and stillbirth rates during the first year of the COVID-19 pandemic: a study of 21 European countries.
Zeitlin J, Philibert M, Barros H, Broeders L, Cap J, Draušnik Ž, Engjom H, Farr A, Fresson J, Gatt M, Gissler M, Heller G, Isakova J, Källén K, Kyprianou T, Loghi M, Monteath K, Mortensen L, Rihs T, Sakkeus L, Sikora I, Szamotulska K, Velebil P, Verdenik I, Weber G, Zile I, Zurriaga O, Smith L; Euro-Peristat Research Group and the Population Health Information Research Infrastructure. Zeitlin J, et al. Eur J Public Health. 2024 Jul 1;34(Supplement_1):i58-i66. doi: 10.1093/eurpub/ckad186. Eur J Public Health. 2024. PMID: 38946450 Free PMC article.
European Health Information Portal: a one-stop shop for health information.
Tolonen H, Saso M, Unim B, Palmieri L, Schutte N, Peyroteo M, Lapão LV, Habl C, Bogaert P; Population Health Information Research Infrastructure and the Health Information Portal. Tolonen H, et al. Eur J Public Health. 2024 Jul 1;34(Supplement_1):i29-i34. doi: 10.1093/eurpub/ckad172. Eur J Public Health. 2024. PMID: 38946446 Free PMC article.
PARP14 is pro- and anti-viral host factor that promotes IFN production and affects the replication of multiple viruses.
Parthasarathy S, Saenjamsai P, Hao H, Ferkul A, Pfannenstiel JJ, Suder EL, Bejan DS, Chen Y, Schwarting N, Aikawa M, Muhlberger E, Orozco RC, Sullivan CS, Cohen MS, Davido DJ, Hume AJ, Fehr AR. Parthasarathy S, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2024 Apr 26:2024.04.26.591186. doi: 10.1101/2024.04.26.591186. bioRxiv. 2024. PMID: 38712082 Free PMC article. Preprint.
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
Wazir S, Parviainen TAO, Pfannenstiel JJ, Duong MTH, Cluff D, Sowa ST, Galera-Prat A, Ferraris D, Maksimainen MM, Fehr AR, Heiskanen JP, Lehtiö L. Wazir S, et al. Among authors: fehr ar. J Med Chem. 2024 Apr 25;67(8):6519-6536. doi: 10.1021/acs.jmedchem.3c02451. Epub 2024 Apr 9. J Med Chem. 2024. PMID: 38592023
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling.
Otter CJ, Bracci N, Parenti NA, Ye C, Asthana A, Blomqvist EK, Tan LH, Pfannenstiel JJ, Jackson N, Fehr AR, Silverman RH, Burke JM, Cohen NA, Martinez-Sobrido L, Weiss SR. Otter CJ, et al. Among authors: fehr ar. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2320194121. doi: 10.1073/pnas.2320194121. Epub 2024 Apr 3. Proc Natl Acad Sci U S A. 2024. PMID: 38568967 Free PMC article.
227 results