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A novel long non-coding RNA connects obesity to impaired adipocyte function.
Lluch A, Latorre J, Oliveras-Cañellas N, Fernández-Sánchez A, Moreno-Navarrete JM, Castells-Nobau A, Comas F, Buxò M, Rodríguez-Hermosa JI, Ballester M, Espadas I, Martín-Montalvo A, Zhang B, Zhou Y, Burkhardt R, Höring M, Liebisch G, Castellanos-Rubio A, Santin I, Kar A, Laakso M, Pajukanta P, Olkkonen VM, Fernández-Real JM, Ortega FJ. Lluch A, et al. Among authors: kar a. Mol Metab. 2024 Dec;90:102040. doi: 10.1016/j.molmet.2024.102040. Epub 2024 Oct 1. Mol Metab. 2024. PMID: 39362599 Free PMC article.
Single nucleus RNA-sequencing integrated into risk variant colocalization discovers 17 cell-type-specific abdominal obesity genes for metabolic dysfunction-associated steatotic liver disease.
Lee SHT, Garske KM, Arasu UT, Kar A, Miao Z, Alvarez M, Koka A, Darci-Maher N, Benhammou JN, Pan DZ, Örd T, Kaminska D, Männistö V, Heinonen S, Wabitsch M, Laakso M, Agopian VG, Pisegna JR, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P. Lee SHT, et al. Among authors: kar a. EBioMedicine. 2024 Aug;106:105232. doi: 10.1016/j.ebiom.2024.105232. Epub 2024 Jul 10. EBioMedicine. 2024. PMID: 38991381 Free PMC article.
An abdominal obesity missense variant in the adipocyte thermogenesis gene TBX15 is implicated in adaptation to cold in Finns.
Deal M, Kar A, Lee SHT, Alvarez M, Rajkumar S, Arasu UT, Kaminska D, Männistö V, Heinonen S, van der Kolk BW, Säiläkivi U, Saarinen T, Juuti A, Pihlajamäki J, Kaikkonen MU, Laakso M, Pietiläinen KH, Pajukanta P. Deal M, et al. Among authors: kar a. Am J Hum Genet. 2024 Nov 7;111(11):2542-2560. doi: 10.1016/j.ajhg.2024.10.001. Am J Hum Genet. 2024. PMID: 39515300 Free PMC article.
Single-cell DNA methylome and 3D genome atlas of the human subcutaneous adipose tissue.
Chen ZJ, Das SS, Kar A, Lee SHT, Abuhanna KD, Alvarez M, Sukhatme MG, Gelev KZ, Heffel MG, Zhang Y, Avram O, Rahmani E, Sankararaman S, Heinonen S, Peltoniemi H, Halperin E, Pietiläinen KH, Luo C, Pajukanta P. Chen ZJ, et al. Among authors: kar a. bioRxiv [Preprint]. 2024 Nov 3:2024.11.02.621694. doi: 10.1101/2024.11.02.621694. bioRxiv. 2024. PMID: 39554055 Free PMC article. Preprint.
Integration of single cell omics with biobank data discovers trans effects of SREBF1 abdominal obesity risk variants on adipocyte expression of more than 100 genes.
Sukhatme MG, Kar A, Arasu UT, Lee SHT, Alvarez M, Garske KM, Gelev KZ, Rajkumar S, Das SS, Kaminska D, Männistö V, Peltoniemi H, Heinonen S, Säiläkivi U, Saarinen T, Juuti A, Pietiläinen KH, Pihlajamäki J, Kaikkonen MU, Pajukanta P. Sukhatme MG, et al. Among authors: kar a. medRxiv [Preprint]. 2024 Nov 23:2024.11.22.24317804. doi: 10.1101/2024.11.22.24317804. medRxiv. 2024. PMID: 39606332 Free PMC article. Preprint.
Comparison of the effect of intraoperative dexmedetomidine versus ketamine on postoperative analgesia in fracture femur patients operated under subarachnoid block - A prospective randomized double-blind controlled trial.
Ather R, Nikhar SA, Kar AK, Durga P, Prasanna PL. Ather R, et al. Among authors: kar ak. J Anaesthesiol Clin Pharmacol. 2024 Oct-Dec;40(4):605-611. doi: 10.4103/joacp.joacp_67_23. Epub 2024 Apr 11. J Anaesthesiol Clin Pharmacol. 2024. PMID: 39759035 Free PMC article.
1,248 results