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Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.
Goold HD, Kroukamp H, Erpf PE, Zhao Y, Kelso P, Calame J, Timmins JJB, Wightman ELI, Peng K, Carpenter AC, Llorente B, Hawthorne C, Clay S, van Wyk N, Daniel EL, Harrison F, Meier F, Willows RD, Cai Y, Walker RSK, Xu X, Espinosa MI, Stracquadanio G, Bader JS, Mitchell LA, Boeke JD, Williams TC, Paulsen IT, Pretorius IS. Goold HD, et al. Among authors: espinosa mi. Nat Commun. 2025 Jan 20;16(1):841. doi: 10.1038/s41467-024-55318-3. Nat Commun. 2025. PMID: 39833175 Free PMC article.
Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects.
Williams TC, Kroukamp H, Xu X, Wightman ELI, Llorente B, Borneman AR, Carpenter AC, Van Wyk N, Meier F, Collier TRV, Espinosa MI, Daniel EL, Walker RSK, Cai Y, Nevalainen HKM, Curach NC, Deveson IW, Mercer TR, Johnson DL, Mitchell LA, Bader JS, Stracquadanio G, Boeke JD, Goold HD, Pretorius IS, Paulsen IT. Williams TC, et al. Among authors: espinosa mi. Cell Genom. 2023 Nov 9;3(11):100379. doi: 10.1016/j.xgen.2023.100379. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020977 Free PMC article.
14 results