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Recent advances in the expanding genetic code.
Pigula ML, Schultz PG. Pigula ML, et al. Among authors: schultz pg. Curr Opin Chem Biol. 2024 Dec;83:102537. doi: 10.1016/j.cbpa.2024.102537. Epub 2024 Oct 3. Curr Opin Chem Biol. 2024. PMID: 39366132 Review.
Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases This work was supported by the National Institutes of Health (GM 60005 to F.E.R.) and the Skaggs Institute for Chemical Biology (F.E.R. and P.G.S.). A.K.O. thanks the National Institutes of Health for a postdoctoral fellowship (F32 GM19833-01).
Berger M, Ogawa AK, McMinn DL, Wu Y, Schultz PG, Romesberg FE. Berger M, et al. Among authors: schultz pg. Angew Chem Int Ed Engl. 2000 Aug 18;39(16):2940-2942. doi: 10.1002/1521-3773(20000818)39:16<2940::aid-anie2940>3.0.co;2-#. Angew Chem Int Ed Engl. 2000. PMID: 11028017 No abstract available.
Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for numerous helpful conversations. J.I.A. and K.G.B were supported by NIH Molecular Biophysics Training Grant (No. T32GM0895). This research was funded by grants to C.R.B. from the Pew Scholars Program, the W. M. Keck Foundation and the American Cancer Society (Grant No. RPG9700501BE).
Armstrong JI, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Bishop A, Gray NS, Shokat KM, Schultz PG, Bertozzi CR. Armstrong JI, et al. Among authors: schultz pg. Angew Chem Int Ed Engl. 2000 Apr;39(7):1303-1306. doi: 10.1002/(sici)1521-3773(20000403)39:7<1303::aid-anie1303>3.0.co;2-0. Angew Chem Int Ed Engl. 2000. PMID: 10767039 No abstract available.
Toward a Quadruplet Codon Mitochondrial Genetic Code.
Pigula ML, Ban Y, Schultz PG. Pigula ML, et al. Among authors: schultz pg. ACS Synth Biol. 2024 Dec 20;13(12):4175-4179. doi: 10.1021/acssynbio.4c00630. Epub 2024 Dec 4. ACS Synth Biol. 2024. PMID: 39631441
A Genetically Encoded Redox-Active Nicotinamide Amino Acid.
Pigula ML, Ban Y, You H, Schultz PG. Pigula ML, et al. Among authors: schultz pg. Biochemistry. 2024 Dec 17;63(24):3184-3188. doi: 10.1021/acs.biochem.4c00530. Epub 2024 Nov 25. Biochemistry. 2024. PMID: 39586687
Synthesis at the Interface of Chemistry and Biology.
Schultz PG. Schultz PG. Acc Chem Res. 2024 Sep 17;57(18):2631-2642. doi: 10.1021/acs.accounts.4c00320. Epub 2024 Aug 28. Acc Chem Res. 2024. PMID: 39198974 Free PMC article. Review.
Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention.
Gupta AK, Pedroarena J, Nazarian A, Antonova-Koch J, Weiss F, Kumpornsin K, Chi V, Woods AK, Lee KJ, Joseph SB, Li S, Brittain J, De Hostos E, Duffy J, Cooper A, Schultz PG, McNamara CW, Chatterjee AK. Gupta AK, et al. Among authors: schultz pg. bioRxiv [Preprint]. 2024 Jul 1:2024.07.01.601566. doi: 10.1101/2024.07.01.601566. bioRxiv. 2024. PMID: 39005341 Free PMC article. Preprint.
A Prodrug Strategy to Reposition Atovaquone as a Long-Acting Injectable for Malaria Chemoprotection.
Gupta AK, Eliasen AM, Andahazy W, Zhou F, Henson K, Chi V, Woods AK, Joseph SB, Kuhen KL, Wisler J, Ramachandruni H, Duffy J, Burrows JN, Vadas E, Slade A, Schultz PG, McNamara CW, Chatterjee AK. Gupta AK, et al. Among authors: schultz pg. bioRxiv [Preprint]. 2024 Jun 25:2024.02.08.579395. doi: 10.1101/2024.02.08.579395. bioRxiv. 2024. PMID: 38979188 Free PMC article. Preprint.
540 results