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De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth.
Gosens R, Baarsma HA, Heijink IH, Oenema TA, Halayko AJ, Meurs H, Schmidt M. Gosens R, et al. FASEB J. 2010 Mar;24(3):757-68. doi: 10.1096/fj.09-136325. Epub 2009 Nov 11. FASEB J. 2010. PMID: 19906679
Collectively, these data indicate that beta-catenin is an important signaling intermediate in airway smooth muscle growth and that its cellular accumulation and nuclear localization require de novo protein synthesis effected, in part, via H-Ras and MEK.-Gosens, R., …
Collectively, these data indicate that beta-catenin is an important signaling intermediate in airway smooth muscle growth and that its cellu …
TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.
Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. Spanjer AI, et al. Among authors: gosens r. FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5. FASEB J. 2016. PMID: 26849959
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for FZD8 in these responses.-Spanjer, A. I. R., Baarsma, H. A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., P …
Collectively, our findings demonstrate a role for FZD8 in TGF-beta-induced profibrotic signaling and imply that WNT-5B may be the ligand for …
TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.
Ng-Blichfeldt JP, de Jong T, Kortekaas RK, Wu X, Lindner M, Guryev V, Hiemstra PS, Stolk J, Königshoff M, Gosens R. Ng-Blichfeldt JP, et al. Among authors: gosens r. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L14-L28. doi: 10.1152/ajplung.00400.2018. Epub 2019 Apr 10. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30969812 Free article.
200 results