Akiyama M - Search Results

1

Multi-defense pathways against electrophiles through adduct formation by low molecular weight substances with sulfur atoms.

Kumagai Y, Abiko Y, Akiyama M, Unoki T, Shinkai Y. Kumagai Y, et al. Among authors: akiyama m. Toxicol Sci. 2025 Jan 1;203(1):1-10. doi: 10.1093/toxsci/kfae132. Toxicol Sci. 2025. PMID: 39374550 Review.

2

Cadmium-Mediated Activation of the HSP90/HSF1 Pathway Regulated by Reactive Persulfides/Polysulfides.

Shinkai Y, Masuda A, Akiyama M, Xian M, Kumagai Y. Shinkai Y, et al. Among authors: akiyama m. Toxicol Sci. 2017 Apr 1;156(2):412-421. doi: 10.1093/toxsci/kfw268. Toxicol Sci. 2017. PMID: 28115653 Free PMC article.

3

Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules.

Kumagai Y, Akiyama M, Unoki T. Kumagai Y, et al. Among authors: akiyama m. Toxicol Res. 2019 Oct;35(4):303-310. doi: 10.5487/TR.2019.35.4.303. Epub 2019 Oct 15. Toxicol Res. 2019. PMID: 31636841 Free PMC article. Review.

4

Spatio-temporal distribution of reactive sulfur species during methylmercury exposure in the rat brain.

Unoki T, Akiyama M, Shinkai Y, Kumagai Y, Fujimura M. Unoki T, et al. Among authors: akiyama m. J Toxicol Sci. 2022;47(1):31-37. doi: 10.2131/jts.47.31. J Toxicol Sci. 2022. PMID: 34987139 Free article.

5

The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity.

Akiyama M, Shinkai Y, Unoki T, Shim I, Ishii I, Kumagai Y. Akiyama M, et al. Chem Res Toxicol. 2017 Dec 18;30(12):2209-2217. doi: 10.1021/acs.chemrestox.7b00278. Epub 2017 Nov 20. Chem Res Toxicol. 2017. PMID: 29116755

6

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation.

Unoki T, Akiyama M, Kumagai Y, Gonçalves FM, Farina M, da Rocha JBT, Aschner M. Unoki T, et al. Among authors: akiyama m. Front Genet. 2018 Sep 12;9:373. doi: 10.3389/fgene.2018.00373. eCollection 2018. Front Genet. 2018. PMID: 30271424 Free PMC article. Review.

7

The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y. Lin J, et al. Among authors: akiyama m. Chem Res Toxicol. 2019 Mar 18;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340. Epub 2019 Feb 7. Chem Res Toxicol. 2019. PMID: 30681327

8

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.

Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y. Akiyama M, et al. Environ Health Perspect. 2019 Jun;127(6):67002. doi: 10.1289/EHP4949. Epub 2019 Jun 5. Environ Health Perspect. 2019. PMID: 31166132 Free PMC article.

9

Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress.

Unoki T, Akiyama M, Kumagai Y. Unoki T, et al. Among authors: akiyama m. Int J Mol Sci. 2020 Jan 15;21(2):545. doi: 10.3390/ijms21020545. Int J Mol Sci. 2020. PMID: 31952233 Free PMC article. Review.

10

Repression of mercury accumulation and adverse effects of methylmercury exposure is mediated by cystathionine γ-lyase to produce reactive sulfur species in mouse brain.

Akiyama M, Unoki T, Yoshida E, Ding Y, Yamakawa H, Shinkai Y, Ishii I, Kumagai Y. Akiyama M, et al. Toxicol Lett. 2020 May 13;330:128-133. doi: 10.1016/j.toxlet.2020.05.007. Online ahead of print. Toxicol Lett. 2020. PMID: 32413476

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