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Cellular senescence by loss of Men1 in osteoblasts is critical for age-related osteoporosis.
Ukon Y, Kaito T, Hirai H, Kitahara T, Bun M, Kodama J, Tateiwa D, Nakagawa S, Ikuta M, Furuichi T, Kanie Y, Fujimori T, Takenaka S, Yamamuro T, Otsuru S, Okada S, Yamashita M, Imamura T. Ukon Y, et al. Among authors: yamamuro t. Aging Cell. 2024 Oct;23(10):e14254. doi: 10.1111/acel.14254. Epub 2024 Jun 22. Aging Cell. 2024. PMID: 39384404 Free PMC article.
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis.
Yamamoto-Imoto H, Minami S, Shioda T, Yamashita Y, Sakai S, Maeda S, Yamamoto T, Oki S, Takashima M, Yamamuro T, Yanagawa K, Edahiro R, Iwatani M, So M, Tokumura A, Abe T, Imamura R, Nonomura N, Okada Y, Ayer DE, Ogawa H, Hara E, Takabatake Y, Isaka Y, Nakamura S, Yoshimori T. Yamamoto-Imoto H, et al. Among authors: yamamuro t. Cell Rep. 2022 Mar 1;38(9):110444. doi: 10.1016/j.celrep.2022.110444. Cell Rep. 2022. PMID: 35235784 Free article.
Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis.
Yoshida G, Kawabata T, Takamatsu H, Saita S, Nakamura S, Nishikawa K, Fujiwara M, Enokidani Y, Yamamuro T, Tabata K, Hamasaki M, Ishii M, Kumanogoh A, Yoshimori T. Yoshida G, et al. Among authors: yamamuro t. Autophagy. 2022 Oct;18(10):2323-2332. doi: 10.1080/15548627.2021.2017587. Epub 2022 Jan 13. Autophagy. 2022. PMID: 35025696 Free PMC article.
The Rubicon-WIPI axis regulates exosome biogenesis during ageing.
Yanagawa K, Kuma A, Hamasaki M, Kita S, Yamamuro T, Nishino K, Nakamura S, Omori H, Kaminishi T, Oikawa S, Kato Y, Edahiro R, Kawagoe R, Taniguchi T, Tanaka Y, Shima T, Tabata K, Iwatani M, Bekku N, Hanayama R, Okada Y, Akimoto T, Kosako H, Takahashi A, Shimomura I, Sakata Y, Yoshimori T. Yanagawa K, et al. Among authors: yamamuro t. Nat Cell Biol. 2024 Sep;26(9):1558-1570. doi: 10.1038/s41556-024-01481-0. Epub 2024 Aug 22. Nat Cell Biol. 2024. PMID: 39174742
Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Takahashi A, Matsuda J, Minami S, Sakai S, Yonishi H, Maeda S, Matsui S, Kawai H, Matsui I, Yamamuro T, Edahiro R, Takashima S, Takasawa A, Okada Y, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. Among authors: yamamuro t. JCI Insight. 2024 Dec 19:e184451. doi: 10.1172/jci.insight.184451. Online ahead of print. JCI Insight. 2024. PMID: 39699959 Free article.
Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
Yamamuro T, Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, Yoshimori T. Yamamuro T, et al. PLoS Genet. 2021 Aug 5;17(8):e1009688. doi: 10.1371/journal.pgen.1009688. eCollection 2021 Aug. PLoS Genet. 2021. PMID: 34351902 Free PMC article.
Suppression of autophagic activity by Rubicon is a signature of aging.
Nakamura S, Oba M, Suzuki M, Takahashi A, Yamamuro T, Fujiwara M, Ikenaka K, Minami S, Tabata N, Yamamoto K, Kubo S, Tokumura A, Akamatsu K, Miyazaki Y, Kawabata T, Hamasaki M, Fukui K, Sango K, Watanabe Y, Takabatake Y, Kitajima TS, Okada Y, Mochizuki H, Isaka Y, Antebi A, Yoshimori T. Nakamura S, et al. Among authors: yamamuro t. Nat Commun. 2019 Feb 19;10(1):847. doi: 10.1038/s41467-019-08729-6. Nat Commun. 2019. PMID: 30783089 Free PMC article.
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S. Wang Q, et al. Among authors: yamamuro t. Nature. 2022 Sep;609(7925):151-158. doi: 10.1038/s41586-022-05067-4. Epub 2022 Aug 17. Nature. 2022. PMID: 35978186 Free PMC article.
394 results