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Operant alcohol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Faccidomo S, et al. bioRxiv [Preprint]. 2024 Nov 14:2024.09.13.612946. doi: 10.1101/2024.09.13.612946. bioRxiv. 2024. Update in: Psychopharmacology (Berl). 2024 Dec 23. doi: 10.1007/s00213-024-06740-4 PMID: 39314444 Free PMC article. Updated. Preprint.
Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Faccidomo S, et al. Psychopharmacology (Berl). 2024 Dec 23. doi: 10.1007/s00213-024-06740-4. Online ahead of print. Psychopharmacology (Berl). 2024. PMID: 39714485
Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice.
Hoffman JL, Faccidomo SP, Taylor SM, DeMiceli KG, May AM, Smith EN, Whindleton CM, Hodge CW. Hoffman JL, et al. Among authors: faccidomo sp. Psychopharmacology (Berl). 2023 Jun;240(6):1261-1273. doi: 10.1007/s00213-023-06365-z. Epub 2023 Apr 13. Psychopharmacology (Berl). 2023. PMID: 37055596 Free PMC article.
Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration.
Hoffman JL, Faccidomo S, Saunders BL, Taylor SM, Kim M, Hodge CW. Hoffman JL, et al. Among authors: faccidomo s. Alcohol Clin Exp Res. 2021 Jul;45(7):1424-1435. doi: 10.1111/acer.14639. Epub 2021 Jun 22. Alcohol Clin Exp Res. 2021. PMID: 34086361 Free PMC article.
Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice.
Torruella-Suárez ML, Vandenberg JR, Cogan ES, Tipton GJ, Teklezghi A, Dange K, Patel GK, McHenry JA, Hardaway JA, Kantak PA, Crowley NA, DiBerto JF, Faccidomo SP, Hodge CW, Stuber GD, McElligott ZA. Torruella-Suárez ML, et al. Among authors: faccidomo sp. J Neurosci. 2020 Jan 15;40(3):632-647. doi: 10.1523/JNEUROSCI.1466-19.2019. Epub 2019 Nov 19. J Neurosci. 2020. PMID: 31744862 Free PMC article.
Pharmacological inhibition of glycogen synthase kinase 3 increases operant alcohol self-administration in a manner associated with altered pGSK-3β, protein interacting with C kinase and GluA2 protein expression in the reward pathway of male C57BL/6J mice.
Faccidomo S, Holstein SE, Santanam TS, Saunders BL, Swaim KS, Reid GT, O'Neill C, Eastman VR, Hodge CW. Faccidomo S, et al. Behav Pharmacol. 2020 Feb;31(1):15-26. doi: 10.1097/FBP.0000000000000501. Behav Pharmacol. 2020. PMID: 31503067 Free PMC article.
36 results