Theunissen TW - Search Results

1

SARS-CoV-2 ORF3a Protein Impairs Syncytiotrophoblast Maturation, Alters ZO-1 Localization, and Shifts Autophagic Pathways in Trophoblast Cells and 3D Organoids.

Kumar D, Karvas RM, Jones BR, McColl ER, Diveley E, Sukanta J, Surendra S, Kelly JC, Theunissen TW, Mysorekar IU. Kumar D, et al. Among authors: theunissen tw. bioRxiv [Preprint]. 2024 Sep 25:2024.09.25.614931. doi: 10.1101/2024.09.25.614931. bioRxiv. 2024. PMID: 39386577 Free PMC article. Preprint.

2

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.

Lam I, Ndayisaba A, Lewis AJ, Fu Y, Sagredo GT, Kuzkina A, Zaccagnini L, Celikag M, Sandoe J, Sanz RL, Vahdatshoar A, Martin TD, Morshed N, Ichihashi T, Tripathi A, Ramalingam N, Oettgen-Suazo C, Bartels T, Boussouf M, Schäbinger M, Hallacli E, Jiang X, Verma A, Tea C, Wang Z, Hakozaki H, Yu X, Hyles K, Park C, Wang X, Theunissen TW, Wang H, Jaenisch R, Lindquist S, Stevens B, Stefanova N, Wenning G, van de Berg WDJ, Luk KC, Sanchez-Pernaute R, Gómez-Esteban JC, Felsky D, Kiyota Y, Sahni N, Yi SS, Chung CY, Stahlberg H, Ferrer I, Schöneberg J, Elledge SJ, Dettmer U, Halliday GM, Bartels T, Khurana V. Lam I, et al. Among authors: theunissen tw. Neuron. 2024 Sep 4;112(17):2886-2909.e16. doi: 10.1016/j.neuron.2024.06.002. Epub 2024 Jul 29. Neuron. 2024. PMID: 39079530 Free PMC article.

3

iPSC-based modeling of preeclampsia identifies epigenetic defects in extravillous trophoblast differentiation.

Morey R, Bui T, Cheung VC, Dong C, Zemke JE, Requena D, Arora H, Jackson MG, Pizzo D, Theunissen TW, Horii M. Morey R, et al. Among authors: theunissen tw. iScience. 2024 Mar 25;27(4):109569. doi: 10.1016/j.isci.2024.109569. eCollection 2024 Apr 19. iScience. 2024. PMID: 38623329 Free PMC article.

4

Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.

Guo M, Wu J, Chen C, Wang X, Gong A, Guan W, Karvas RM, Wang K, Min M, Wang Y, Theunissen TW, Gao S, Silva JCR. Guo M, et al. Among authors: theunissen tw. Nat Commun. 2024 Jan 22;15(1):668. doi: 10.1038/s41467-024-44969-x. Nat Commun. 2024. PMID: 38253551 Free PMC article.

5

3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages.

Karvas RM, Zemke JE, Ali SS, Upton E, Sane E, Fischer LA, Dong C, Park KM, Wang F, Park K, Hao S, Chew B, Meyer B, Zhou C, Dietmann S, Theunissen TW. Karvas RM, et al. Among authors: theunissen tw. Cell Stem Cell. 2023 Sep 7;30(9):1148-1165.e7. doi: 10.1016/j.stem.2023.08.005. Cell Stem Cell. 2023. PMID: 37683602 Free article.

6

Modeling X-chromosome inactivation and reactivation during human development.

Khan SA, Theunissen TW. Khan SA, et al. Among authors: theunissen tw. Curr Opin Genet Dev. 2023 Oct;82:102096. doi: 10.1016/j.gde.2023.102096. Epub 2023 Aug 17. Curr Opin Genet Dev. 2023. PMID: 37597506 Free PMC article. Review.

7

Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells.

Karvas RM, Theunissen TW. Karvas RM, et al. Among authors: theunissen tw. Methods Mol Biol. 2024;2767:85-103. doi: 10.1007/7651_2023_496. Methods Mol Biol. 2024. PMID: 37402094 Free PMC article.

8

Accessing the human trophoblast stem cell state from pluripotent and somatic cells.

Karvas RM, David L, Theunissen TW. Karvas RM, et al. Among authors: theunissen tw. Cell Mol Life Sci. 2022 Nov 25;79(12):604. doi: 10.1007/s00018-022-04549-y. Cell Mol Life Sci. 2022. PMID: 36434136 Free PMC article. Review.

9

A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells.

Dong C, Fu S, Karvas RM, Chew B, Fischer LA, Xing X, Harrison JK, Popli P, Kommagani R, Wang T, Zhang B, Theunissen TW. Dong C, et al. Among authors: theunissen tw. Nat Commun. 2022 May 10;13(1):2548. doi: 10.1038/s41467-022-30207-9. Nat Commun. 2022. PMID: 35538076 Free PMC article.

10

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.

Karvas RM, Khan SA, Verma S, Yin Y, Kulkarni D, Dong C, Park KM, Chew B, Sane E, Fischer LA, Kumar D, Ma L, Boon ACM, Dietmann S, Mysorekar IU, Theunissen TW. Karvas RM, et al. Among authors: theunissen tw. Cell Stem Cell. 2022 May 5;29(5):810-825.e8. doi: 10.1016/j.stem.2022.04.004. Cell Stem Cell. 2022. PMID: 35523141 Free PMC article.

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