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A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection.
Kang N, Chawla A, Hillman H, Tippalagama R, Kim C, Mikulski Z, Seumois G, Vijayanand P, Scriba TJ, De Silva AD, Balmaseda A, Harris E, Weiskopf D, Sette A, Arlehamn CL, Peters B, Burel JG. Kang N, et al. Among authors: tippalagama r. bioRxiv [Preprint]. 2024 Sep 23:2024.09.20.612103. doi: 10.1101/2024.09.20.612103. bioRxiv. 2024. PMID: 39386643 Free PMC article. Preprint.
Putting computational models of immunity to the test - an invited challenge to predict B. pertussis vaccination outcomes.
Shinde P, Willemsen L, Anderson M, Aoki M, Basu S, Burel JG, Cheng P, Dastidar SG, Dunleavy A, Einav T, Forschmiedt J, Fourati S, Garcia J, Gibson W, Greenbaum JA, Guan L, Guan W, Gygi JP, Ha B, Hou J, Hsiao J, Huang Y, Jansen R, Kakoty B, Kang Z, Kobie JJ, Kojima M, Konstorum A, Lee J, Lewis SA, Li A, Lock EF, Mahita J, Mendes M, Meng H, Neher A, Nili S, Olsen LR, Orfield S, Overton JA, Pai N, Parker C, Qian B, Rasmussen M, Reyna J, Richardson E, Safo S, Sorenson J, Srinivasan A, Thrupp N, Tippalagama R, Trevizani R, Ventz S, Wang J, Wu CC, Ay F, Grant B, Kleinstein SH, Peters B. Shinde P, et al. Among authors: tippalagama r. bioRxiv [Preprint]. 2024 Sep 8:2024.09.04.611290. doi: 10.1101/2024.09.04.611290. bioRxiv. 2024. PMID: 39282381 Free PMC article. Preprint.
Single-cell profiling reveals distinct subsets of CD14+ monocytes drive blood immune signatures of active tuberculosis.
Hillman H, Khan N, Singhania A, Dubelko P, Soldevila F, Tippalagama R, DeSilva AD, Gunasena B, Perera J, Scriba TJ, Ontong C, Fisher M, Luabeya A, Taplitz R, Seumois G, Vijayanand P, Hedrick CC, Peters B, Burel JG. Hillman H, et al. Among authors: tippalagama r. Front Immunol. 2023 Jan 11;13:1087010. doi: 10.3389/fimmu.2022.1087010. eCollection 2022. Front Immunol. 2023. PMID: 36713384 Free PMC article.
Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity.
Grifoni A, Voic H, Yu ED, Mateus J, Yan Fung KM, Wang A, Seumois G, De Silva AD, Tennekon R, Premawansa S, Premawansa G, Tippalagama R, Wijewickrama A, Chawla A, Greenbaum J, Peters B, Pandurangan V, Weiskopf D, Sette A. Grifoni A, et al. Among authors: tippalagama r. Vaccines (Basel). 2022 Apr 14;10(4):612. doi: 10.3390/vaccines10040612. Vaccines (Basel). 2022. PMID: 35455361 Free PMC article.
HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients.
Tippalagama R, Singhania A, Dubelko P, Lindestam Arlehamn CS, Crinklaw A, Pomaznoy M, Seumois G, deSilva AD, Premawansa S, Vidanagama D, Gunasena B, Goonawardhana NDS, Ariyaratne D, Scriba TJ, Gilman RH, Saito M, Taplitz R, Vijayanand P, Sette A, Peters B, Burel JG. Tippalagama R, et al. J Immunol. 2021 Jul 15;207(2):523-533. doi: 10.4049/jimmunol.2100011. Epub 2021 Jun 30. J Immunol. 2021. PMID: 34193602 Free PMC article.
Classical CD4 T cells as the cornerstone of antimycobacterial immunity.
Morgan J, Muskat K, Tippalagama R, Sette A, Burel J, Lindestam Arlehamn CS. Morgan J, et al. Among authors: tippalagama r. Immunol Rev. 2021 May;301(1):10-29. doi: 10.1111/imr.12963. Epub 2021 Mar 9. Immunol Rev. 2021. PMID: 33751597 Free PMC article. Review.
Circulating T cell-monocyte complexes are markers of immune perturbations.
Burel JG, Pomaznoy M, Lindestam Arlehamn CS, Weiskopf D, da Silva Antunes R, Jung Y, Babor M, Schulten V, Seumois G, Greenbaum JA, Premawansa S, Premawansa G, Wijewickrama A, Vidanagama D, Gunasena B, Tippalagama R, deSilva AD, Gilman RH, Saito M, Taplitz R, Ley K, Vijayanand P, Sette A, Peters B. Burel JG, et al. Among authors: tippalagama r. Elife. 2019 Jun 25;8:e46045. doi: 10.7554/eLife.46045. Elife. 2019. PMID: 31237234 Free PMC article.
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.
Grifoni A, Weiskopf D, Lindestam Arlehamn CS, Angelo M, Leary S, Sidney J, Frazier A, Phillips E, Mallal S, Mack SJ, Tippalagama R, Goonewardana S, Premawansa S, Premawansa G, Wijewickrama A, De Silva AD, Sette A. Grifoni A, et al. Among authors: tippalagama r. Hum Immunol. 2018 Feb;79(2):87-88. doi: 10.1016/j.humimm.2017.12.007. Epub 2017 Dec 28. Hum Immunol. 2018. PMID: 29289740 Free PMC article.
13 results