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Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility.
Ostrom EL, Stuppard R, Mattson-Hughes A, Marcinek DJ. Ostrom EL, et al. Among authors: mattson hughes a. bioRxiv [Preprint]. 2024 Sep 25:2024.09.23.614547. doi: 10.1101/2024.09.23.614547. bioRxiv. 2024. Update in: Free Radic Biol Med. 2025 Jan;226:237-250. doi: 10.1016/j.freeradbiomed.2024.10.310 PMID: 39386714 Free PMC article. Updated. Preprint.