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Page 1
Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits.
Perdok A, Van Acker ZP, Vrancx C, Sannerud R, Vorsters I, Verrengia A, Callaerts-Végh Z, Creemers E, Gutiérrez Fernández S, D'hauw B, Serneels L, Wierda K, Chávez-Gutiérrez L, Annaert W. Perdok A, et al. Among authors: wierda k. Nat Commun. 2024 Nov 29;15(1):10412. doi: 10.1038/s41467-024-54777-y. Nat Commun. 2024. PMID: 39613768 Free PMC article.
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition.
Libé-Philippot B, Iwata R, Recupero AJ, Wierda K, Bernal Garcia S, Hammond L, van Benthem A, Limame R, Ditkowska M, Beckers S, Gaspariunaite V, Peze-Heidsieck E, Remans D, Charrier C, Theys T, Polleux F, Vanderhaeghen P. Libé-Philippot B, et al. Among authors: wierda k. Neuron. 2024 Nov 6;112(21):3602-3617.e9. doi: 10.1016/j.neuron.2024.08.021. Epub 2024 Oct 14. Neuron. 2024. PMID: 39406239 Free PMC article.
Corrigendum to "Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells" [Biochem. Pharmacol. 227 (2024) 116445].
De Vos K, Mavrogiannis A, Wolters JC, Schlenner S, Wierda K, Calabuig ÁC, Chinnaraj R, Dermesrobian V, Armoudjian Y, Jacquemyn M, Corthout N, Daelemans D, Annaert P. De Vos K, et al. Among authors: wierda k. Biochem Pharmacol. 2024 Nov;229:116497. doi: 10.1016/j.bcp.2024.116497. Epub 2024 Aug 22. Biochem Pharmacol. 2024. PMID: 39178689 No abstract available.
Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells.
De Vos K, Mavrogiannis A, Wolters JC, Schlenner S, Wierda K, Cortés Calabuig Á, Chinnaraj R, Dermesrobian V, Armoudjian Y, Jacquemyn M, Corthout N, Daelemans D, Annaert P. De Vos K, et al. Among authors: wierda k. Biochem Pharmacol. 2024 Sep;227:116445. doi: 10.1016/j.bcp.2024.116445. Epub 2024 Jul 23. Biochem Pharmacol. 2024. PMID: 39053638
Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.
Bretou M, Sannerud R, Escamilla-Ayala A, Leroy T, Vrancx C, Van Acker ZP, Perdok A, Vermeire W, Vorsters I, Van Keymolen S, Maxson M, Pavie B, Wierda K, Eskelinen EL, Annaert W. Bretou M, et al. Among authors: wierda k. Dev Cell. 2024 Jun 17;59(12):1571-1592.e9. doi: 10.1016/j.devcel.2024.03.030. Epub 2024 Apr 15. Dev Cell. 2024. PMID: 38626765 Free article.
An immunological puzzle: The adaptive immune system fuels Alzheimer's disease pathology.
Van Hoecke L, Castelein J, Xie J, Van Acker L, Van Imschoot G, Van Wonterghem E, Vlaeminck I, Verhaege D, Claeys W, Wierda K, Callaerts-Vegh Z, Vandenbroucke RE. Van Hoecke L, et al. Among authors: wierda k. Brain Behav Immun. 2024 Mar;117:122-134. doi: 10.1016/j.bbi.2023.12.026. Epub 2023 Dec 23. Brain Behav Immun. 2024. PMID: 38142916
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.
Libé-Philippot B, Lejeune A, Wierda K, Louros N, Erkol E, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Konstantoulea K, Nyitrai H, De Vleeschouwer M, Vennekens KM, Vidal N, Bird TW, Soto DC, Jaspers T, Dewilde M, Dennis MY, Rousseau F, Comoletti D, Schymkowitz J, Theys T, de Wit J, Vanderhaeghen P. Libé-Philippot B, et al. Among authors: wierda k. Cell. 2023 Dec 21;186(26):5766-5783.e25. doi: 10.1016/j.cell.2023.11.028. Cell. 2023. PMID: 38134874 Free PMC article.
Spatially Self-Organized Three-Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development.
Chai YC, To SK, Simorgh S, Zaunz S, Zhu Y, Ahuja K, Lemaitre A, Ramezankhani R, van der Veer BK, Wierda K, Verhulst S, van Grunsven LA, Pasque V, Verfaillie C. Chai YC, et al. Among authors: wierda k. Adv Sci (Weinh). 2024 Feb;11(5):e2304421. doi: 10.1002/advs.202304421. Epub 2023 Nov 30. Adv Sci (Weinh). 2024. PMID: 38037510 Free PMC article.
43 results