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Page 1
Building Metabolically Stable and Potent Anti-HIV Thioether-Lipid Analogues of Tenofovir Exalidex: A thorough Pharmacological Analysis.
D'Erasmo MP, Sharma SK, Pribut N, Basson A, Dasari M, Bartsch P, Iskandar SE, Giesler KE, Burton S, Derdeyn CA, Liotta DC, Miller EJ. D'Erasmo MP, et al. Among authors: derdeyn ca. J Med Chem. 2024 Oct 24;67(20):18204-18220. doi: 10.1021/acs.jmedchem.4c01510. Epub 2024 Oct 16. J Med Chem. 2024. PMID: 39411803 Free PMC article.
Expanding the toolbox of metabolically stable lipid prodrug strategies.
Toti KS, Pribut N, D'Erasmo M, Dasari M, Sharma SK, Bartsch PW, Burton SL, Gold HB, Bushnev A, Derdeyn CA, Basson AE, Liotta DC, Miller EJ. Toti KS, et al. Among authors: derdeyn ca. Front Pharmacol. 2023 Jan 6;13:1083284. doi: 10.3389/fphar.2022.1083284. eCollection 2022. Front Pharmacol. 2023. PMID: 36686712 Free PMC article.
High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope.
Mopuri R, Welbourn S, Charles T, Ralli-Jain P, Rosales D, Burton S, Aftab A, Karunakaran K, Pellegrini K, Kilembe W, Karita E, Gnanakaran S, Upadhyay AA, Bosinger SE, Derdeyn CA. Mopuri R, et al. Among authors: derdeyn ca. PLoS Pathog. 2023 Oct 25;19(10):e1011717. doi: 10.1371/journal.ppat.1011717. eCollection 2023 Oct. PLoS Pathog. 2023. PMID: 37878666 Free PMC article.
Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.
Bollimpelli VS, Reddy PBJ, Gangadhara S, Charles TP, Burton SL, Tharp GK, Styles TM, Labranche CC, Smith JC, Upadhyay AA, Sahoo A, Legere T, Shiferaw A, Velu V, Yu T, Tomai M, Vasilakos J, Kasturi SP, Shaw GM, Montefiori D, Bosinger SE, Kozlowski PA, Pulendran B, Derdeyn CA, Hunter E, Amara RR. Bollimpelli VS, et al. Among authors: derdeyn ca. Nat Commun. 2023 Aug 8;14(1):4789. doi: 10.1038/s41467-023-40430-7. Nat Commun. 2023. PMID: 37553348 Free PMC article.
V2 hotspot optimized MVA vaccine expressing stabilized HIV-1 Clade C envelope Gp140 delays acquisition of heterologous Clade C Tier 2 challenges in Mamu-A*01 negative Rhesus Macaques.
Styles TM, Gangadhara S, Reddy PBJ, Sahoo A, Shiferaw A, Welbourn S, Kozlowski PA, Derdeyn CA, Velu V, Amara RR. Styles TM, et al. Among authors: derdeyn ca. Front Immunol. 2022 Jul 22;13:914969. doi: 10.3389/fimmu.2022.914969. eCollection 2022. Front Immunol. 2022. PMID: 35935987 Free PMC article.
A clade C HIV-1 vaccine protects against heterologous SHIV infection by modulating IgG glycosylation and T helper response in macaques.
Sahoo A, Jones AT, Cheedarla N, Gangadhara S, Roy V, Styles TM, Shiferaw A, Walter KL, Williams LD, Shen X, Ozorowski G, Lee WH, Burton S, Yi L, Song X, Qin ZS, Derdeyn CA, Ward AB, Clements JD, Varadarajan R, Tomaras GD, Kozlowski PA, Alter G, Amara RR. Sahoo A, et al. Among authors: derdeyn ca. Sci Immunol. 2022 Jul 22;7(73):eabl4102. doi: 10.1126/sciimmunol.abl4102. Epub 2022 Jul 22. Sci Immunol. 2022. PMID: 35867800 Free PMC article.
A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
Welbourn S, Chakraborty S, Yang JE, Gleinich AS, Gangadhara S, Khan S, Ferrebee C, Yagnik B, Burton S, Charles T, Smith SA, Williams D, Mopuri R, Upadhyay AA, Thompson J, Price MA, Wang S, Qin Z, Shen X, Williams LD, Eisel N, Peters T, Zhang L, Kilembe W, Karita E, Tomaras GD, Bosinger SE, Amara RR, Azadi P, Wright ER, Gnanakaran S, Derdeyn CA. Welbourn S, et al. Among authors: derdeyn ca. PLoS Pathog. 2022 May 3;18(5):e1010488. doi: 10.1371/journal.ppat.1010488. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35503780 Free PMC article.
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Jecs E, Tahirovic YA, Wilson RJ, Miller EJ, Kim M, Truax V, Nguyen HH, Akins NS, Saindane M, Wang T, Sum CS, Cvijic ME, Schroeder GM, Burton SL, Derdeyn CA, Xu L, Jiang Y, Wilson LJ, Liotta DC. Jecs E, et al. Among authors: derdeyn ca. J Med Chem. 2022 Mar 10;65(5):4058-4084. doi: 10.1021/acs.jmedchem.1c01564. Epub 2022 Feb 18. J Med Chem. 2022. PMID: 35179893
99 results