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Page 1
The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell.
Hara Y, Jha MK, Huang JY, Han Y, Langohr IM, Gaglia G, Zhu C, Piepenhagen P, Gayvert K, Lim WK, Asrat S, Nash S, Jacob-Nara JA, Orengo JM, Bangari DS, de Rinaldis E, Mattoo H, Hicks A. Hara Y, et al. Among authors: lim wk. Allergy. 2024 Oct 17. doi: 10.1111/all.16338. Online ahead of print. Allergy. 2024. PMID: 39418114
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.
Le Floc'h A, Allinne J, Nagashima K, Scott G, Birchard D, Asrat S, Bai Y, Lim WK, Martin J, Huang T, Potocky TB, Kim JH, Rafique A, Papadopoulos NJ, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: lim wk. Allergy. 2020 May;75(5):1188-1204. doi: 10.1111/all.14151. Epub 2020 Jan 3. Allergy. 2020. PMID: 31838750 Free PMC article.
Nasal brushing molecular endotyping distinguishes patients with chronic rhinosinusitis with nasal polyps with better response to dupilumab.
Gayvert K, Desrosiers M, Laidlaw TM, Mannent LP, Patel K, Horowitz J, Amin N, Jagerschmidt A, Hamilton JD, Lim WK, Harel S. Gayvert K, et al. Among authors: lim wk. J Allergy Clin Immunol. 2024 Sep;154(3):619-630. doi: 10.1016/j.jaci.2024.05.030. Epub 2024 Jun 14. J Allergy Clin Immunol. 2024. PMID: 38880251 Free article. Clinical Trial.
IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation.
Allinne J, Scott G, Lim WK, Birchard D, Erjefält JS, Sandén C, Ben LH, Agrawal A, Kaur N, Kim JH, Kamat V, Fury W, Huang T, Stahl N, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Allinne J, et al. Among authors: lim wk. J Allergy Clin Immunol. 2019 Dec;144(6):1624-1637.e10. doi: 10.1016/j.jaci.2019.08.039. Epub 2019 Sep 25. J Allergy Clin Immunol. 2019. PMID: 31562870 Free article.
Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Le Floc'h A, Nagashima K, Birchard D, Scott G, Ben LH, Ajithdoss D, Gayvert K, Romero Hernandez A, Herbin O, Tay A, Farrales P, Korgaonkar CK, Pan H, Shah S, Kamat V, Chatterjee I, Popke J, Oyejide A, Lim WK, Kim JH, Huang T, Franklin M, Olson W, Norton T, Perlee L, Yancopoulos GD, Murphy AJ, Sleeman MA, Orengo JM. Le Floc'h A, et al. Among authors: lim wk. Sci Transl Med. 2023 Jan 11;15(678):eabo0205. doi: 10.1126/scitranslmed.abo0205. Epub 2023 Jan 11. Sci Transl Med. 2023. PMID: 36630481
TRAPnSeq allows high-throughput profiling of antigen-specific antibody-secreting cells.
Asrat S, Devlin JC, Vecchione A, Klotz B, Setliff I, Srivastava D, Limnander A, Rafique A, Adler C, Porter S, Murphy AJ, Atwal GS, Sleeman MA, Lim WK, Orengo JM. Asrat S, et al. Among authors: lim wk. Cell Rep Methods. 2023 Jul 7;3(7):100522. doi: 10.1016/j.crmeth.2023.100522. eCollection 2023 Jul 24. Cell Rep Methods. 2023. PMID: 37533642 Free PMC article.
IgE plasma cells are transcriptionally and functionally distinct from other isotypes.
Vecchione A, Devlin JC, Tasker C, Ramnarayan VR, Haase P, Conde E, Srivastava D, Atwal GS, Bruhns P, Murphy AJ, Sleeman MA, Limnander A, Lim WK, Asrat S, Orengo JM. Vecchione A, et al. Among authors: lim wk. Sci Immunol. 2024 Sep 6;9(99):eadm8964. doi: 10.1126/sciimmunol.adm8964. Epub 2024 Sep 6. Sci Immunol. 2024. PMID: 39241058
Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning.
Wipperman MF, Lin AZ, Gayvert KM, Lahner B, Somersan-Karakaya S, Wu X, Im J, Lee M, Koyani B, Setliff I, Thakur M, Duan D, Breazna A, Wang F, Lim WK, Halasz G, Urbanek J, Patel Y, Atwal GS, Hamilton JD, Stuart S, Levy O, Avbersek A, Alaj R, Hamon SC, Harari O. Wipperman MF, et al. Among authors: lim wk. Elife. 2024 Apr 30;13:e86132. doi: 10.7554/eLife.86132. Elife. 2024. PMID: 38686919 Free PMC article.
Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine.
Hovhannisyan Z, Liu N, Khalil-Aguero S, Panea C, VanValkenburgh J, Zhang R, Lim WK, Bai Y, Fury W, Huang T, Garnova E, Fairhurst J, Kim J, Aryal S, Ajithdoss D, Oyejide A, Del Pilar Molina-Portela M, E H, Poueymirou W, Oristian NS, Brydges S, Liu X, Olson W, Yancopoulos G, Murphy AJ, Sleeman MA, Haxhinasto S. Hovhannisyan Z, et al. Among authors: lim wk. Sci Immunol. 2020 Dec 18;5(54):eaax1686. doi: 10.1126/sciimmunol.aax1686. Sci Immunol. 2020. PMID: 33443029
356 results