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Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells.
Myers CG, Viswambharan H, Haywood NJ, Bridge K, Turvey S, Armstrong T, Lunn L, Meakin PJ, Porter KE, Clavane EM, Beech DJ, Cubbon RM, Wheatcroft SB, McPhillie MJ, Issad T, Fishwick CW, Kearney MT, Simmons KJ. Myers CG, et al. Among authors: simmons kj. Mol Cell Endocrinol. 2024 Dec 1;594:112387. doi: 10.1016/j.mce.2024.112387. Epub 2024 Oct 16. Mol Cell Endocrinol. 2024. PMID: 39419341 Free article.
The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis.
Wasson CW, De Lorenzis E, Clavane EM, Ross RL, Walker KA, Caballero-Ruiz B, Antinozzi C, Wells R, Migneco G, Brown JMY, Turvey SJ, Simmons KJ, Riobo-Del Galdo NA, Di Luigi L, McKimmie CS, Del Galdo F, Meakin PJ. Wasson CW, et al. Among authors: simmons kj. J Invest Dermatol. 2024 Oct;144(10):2197-2210.e4. doi: 10.1016/j.jid.2024.03.024. Epub 2024 Apr 1. J Invest Dermatol. 2024. PMID: 38570030 Free article.
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.
Luk C, Bridge KI, Warmke N, Simmons KJ, Drozd M, Moran A, MacCannell ADV, Cheng CW, Straw S, Scragg JL, Smith J, Ozber CH, Wilkinson CG, Skromna A, Makava N, Prag HA, Simon Futers T, Brown OI, Bruns AF, Walker AM, Watt NT, Mughal R, Griffin KJ, Yuldasheva NY, Limumpornpetch S, Viswambharan H, Sukumar P, Beech DJ, Vidal-Puig A, Witte KK, Murphy MP, Hartley RC, Wheatcroft SB, Cubbon RM, Roberts LD, Kearney MT, Haywood NJ. Luk C, et al. Among authors: simmons kj. Nat Commun. 2025 Jan 2;16(1):170. doi: 10.1038/s41467-024-54669-1. Nat Commun. 2025. PMID: 39747815 Free PMC article.
Cixutumumab reveals a critical role for IGF-1 in adipose and hepatic tissue remodelling during the development of diet-induced obesity.
Imrie H, Viswambharan H, Haywood NJ, Bridge KI, Yuldasheva NY, Galloway S, Simmons KJ, Cubbon RM, Sukumar P, Watt NT, Lichtenstein L, Wyatt JI, Kudo H, Goldin R, Rode B, Wheatcroft SB, Kearney MT. Imrie H, et al. Among authors: simmons kj. Adipocyte. 2022 Dec;11(1):366-378. doi: 10.1080/21623945.2022.2089394. Adipocyte. 2022. PMID: 35734881 Free PMC article.
42 results