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Lomitapide for the treatment of paediatric patients with homozygous familial hypercholesterolaemia (APH-19): results from the efficacy phase of an open-label, multicentre, phase 3 study.
Masana L, Zambon A, Schmitt CP, Taylan C, Driemeyer J, Cohen H, Buonuomo PS, Alashwal A, Al-Dubayee M, Kholaif N, Diaz-Diaz JL, Maatouk F, Martinez-Hervas S, Mangal B, Löwe S, Cunningham T. Masana L, et al. Among authors: lowe s. Lancet Diabetes Endocrinol. 2024 Dec;12(12):880-889. doi: 10.1016/S2213-8587(24)00233-X. Epub 2024 Oct 16. Lancet Diabetes Endocrinol. 2024. PMID: 39426393 Clinical Trial.
Efficacy and safety of Oleogel-S10 (birch triterpenes) for epidermolysis bullosa: results from the phase III randomized double-blind phase of the EASE study.
Kern JS, Sprecher E, Fernandez MF, Schauer F, Bodemer C, Cunningham T, Löwe S, Davis C, Sumeray M, Bruckner AL, Murrell DF; EASE investigators. Kern JS, et al. Among authors: lowe s. Br J Dermatol. 2023 Jan 23;188(1):12-21. doi: 10.1093/bjd/ljac001. Br J Dermatol. 2023. PMID: 36689495 Clinical Trial.
α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia.
Millman SE, Chaves-Perez A, Janaki-Raman S, Ho YJ, Morris Iv JP, Narendra V, Chen CC, Jackson BT, Yashinskie JJ, Mezzadra R, Devine TI, Barthet VJA, Saoi M, Baslan T, Tian S, Sachs Z, Finley LW, Cross JR, Lowe SW. Millman SE, et al. Among authors: lowe sw. Blood. 2024 Dec 27:blood.2024025245. doi: 10.1182/blood.2024025245. Online ahead of print. Blood. 2024. PMID: 39791576
Discovery and clinical translation of ceperognastat, an O-GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease.
Kielbasa W, Goldsmith P, Donnelly KB, Nuthall HN, Shcherbinin S, Fleisher AS, Hendle J, DuBois SL, Lowe SL, Zhang FF, Woerly EM, Dreyfus NJ, Evans D, Gilmore J, Mancini M, Constantinescu CC, Gunn RN, Russell DS, Collins EC, Brys M, Hutton ML, Mergott DJ. Kielbasa W, et al. Among authors: lowe sl. Alzheimers Dement (N Y). 2024 Dec 26;10(4):e70020. doi: 10.1002/trc2.70020. eCollection 2024 Oct-Dec. Alzheimers Dement (N Y). 2024. PMID: 39748851 Free PMC article.
1,159 results