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Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Avellaneda Matteo D, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Mealka M, et al. Among authors: komives ea. Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2. Nat Commun. 2024. PMID: 38710674 Free PMC article.
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sabo KA, Albekioni E, Caliger D, Coleman NJ, Thornberg E, Avellaneda Matteo D, Komives EA, Silletti S, Sohl CD. Sabo KA, et al. Among authors: komives ea. Biochemistry. 2023 Mar 21;62(6):1145-1159. doi: 10.1021/acs.biochem.2c00636. Epub 2023 Feb 28. Biochemistry. 2023. PMID: 36854124 Free PMC article.
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.
Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD. Mealka M, et al. Among authors: komives ea. Res Sq [Preprint]. 2024 Feb 23:rs.3.rs-3889456. doi: 10.21203/rs.3.rs-3889456/v1. Res Sq. 2024. Update in: Nat Commun. 2024 May 6;15(1):3785. doi: 10.1038/s41467-024-48277-2 PMID: 38464189 Free PMC article. Updated. Preprint.
Surveying biomolecular frustration at atomic resolution.
Chen M, Chen X, Schafer NP, Clementi C, Komives EA, Ferreiro DU, Wolynes PG. Chen M, et al. Among authors: komives ea. Nat Commun. 2020 Nov 23;11(1):5944. doi: 10.1038/s41467-020-19560-9. Nat Commun. 2020. PMID: 33230150 Free PMC article.
Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. Lumpkin RJ, et al. Among authors: komives ea. Nat Commun. 2020 Jun 8;11(1):2866. doi: 10.1038/s41467-020-16499-9. Nat Commun. 2020. PMID: 32513959 Free PMC article.
198 results