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Page 1
Soluble CD146 cooperates with VEGF-A to generate an immunosuppressive microenvironment in CD146-positive tumors: interest of a combined antibody-based therapy.
Joshkon A, Traboulsi W, Terme M, Bachelier R, Fayyad-Kazan H, Dignat-George F, Foucault-Bertaud A, Leroyer AS, Bardin N, Blot-Chabaud M. Joshkon A, et al. Among authors: foucault bertaud a. Mol Cancer Ther. 2024 Oct 21. doi: 10.1158/1535-7163.MCT-24-0008. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39431288
Therapeutic targeting of soluble CD146/MCAM with the M2J-1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146-positive invasive tumors.
Stalin J, Traboulsi W, Vivancos-Stalin L, Nollet M, Joshkon A, Bachelier R, Guillet B, Lacroix R, Foucault-Bertaud A, Leroyer AS, Dignat-George F, Bardin N, Blot-Chabaud M. Stalin J, et al. Int J Cancer. 2020 Sep 15;147(6):1666-1679. doi: 10.1002/ijc.32909. Epub 2020 Feb 22. Int J Cancer. 2020. PMID: 32022257
Soluble CD146 displays angiogenic properties and promotes neovascularization in experimental hind-limb ischemia.
Harhouri K, Kebir A, Guillet B, Foucault-Bertaud A, Voytenko S, Piercecchi-Marti MD, Berenguer C, Lamy E, Vely F, Pisano P, Ouafik L, Sabatier F, Sampol J, Bardin N, Dignat-George F, Blot-Chabaud M. Harhouri K, et al. Blood. 2010 May 6;115(18):3843-51. doi: 10.1182/blood-2009-06-229591. Epub 2010 Feb 25. Blood. 2010. PMID: 20185588 Free article.
Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform.
Stalin J, Harhouri K, Hubert L, Garrigue P, Nollet M, Essaadi A, Muller A, Foucault-Bertaud A, Bachelier R, Sabatier F, Pisano P, Peiretti F, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Stalin J, et al. Cardiovasc Res. 2016 Aug 1;111(3):240-51. doi: 10.1093/cvr/cvw096. Epub 2016 May 11. Cardiovasc Res. 2016. PMID: 27170199
A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule.
Nollet M, Stalin J, Moyon A, Traboulsi W, Essaadi A, Robert S, Malissen N, Bachelier R, Daniel L, Foucault-Bertaud A, Gaudy-Marqueste C, Lacroix R, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Nollet M, et al. Oncotarget. 2017 Nov 28;8(68):112283-112296. doi: 10.18632/oncotarget.22736. eCollection 2017 Dec 22. Oncotarget. 2017. PMID: 29348825 Free PMC article.
CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment.
Blin MG, Bachelier R, Fallague K, Moussouni K, Aurrand-Lions M, Fernandez S, Guillet B, Robert S, Foucault-Bertaud A, Bardin N, Blot-Chabaud M, Dignat-George F, Leroyer AS. Blin MG, et al. J Mol Cell Cardiol. 2019 May;130:76-87. doi: 10.1016/j.yjmcc.2019.03.017. Epub 2019 Mar 27. J Mol Cell Cardiol. 2019. PMID: 30928429
CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases.
Heim X, Joshkon A, Bermudez J, Bachelier R, Dubrou C, Boucraut J, Foucault-Bertaud A, Leroyer AS, Dignat-George F, Blot-Chabaud M, Bardin N. Heim X, et al. Among authors: foucault bertaud a. Biomedicines. 2020 Dec 10;8(12):592. doi: 10.3390/biomedicines8120592. Biomedicines. 2020. PMID: 33321883 Free PMC article. Review.
30 results