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Page 1
Soluble CD146 cooperates with VEGF-A to generate an immunosuppressive microenvironment in CD146-positive tumors: interest of a combined antibody-based therapy.
Joshkon A, Traboulsi W, Terme M, Bachelier R, Fayyad-Kazan H, Dignat-George F, Foucault-Bertaud A, Leroyer AS, Bardin N, Blot-Chabaud M. Joshkon A, et al. Among authors: leroyer as. Mol Cancer Ther. 2024 Oct 21. doi: 10.1158/1535-7163.MCT-24-0008. Online ahead of print. Mol Cancer Ther. 2024. PMID: 39431288
Therapeutic targeting of soluble CD146/MCAM with the M2J-1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146-positive invasive tumors.
Stalin J, Traboulsi W, Vivancos-Stalin L, Nollet M, Joshkon A, Bachelier R, Guillet B, Lacroix R, Foucault-Bertaud A, Leroyer AS, Dignat-George F, Bardin N, Blot-Chabaud M. Stalin J, et al. Among authors: leroyer as. Int J Cancer. 2020 Sep 15;147(6):1666-1679. doi: 10.1002/ijc.32909. Epub 2020 Feb 22. Int J Cancer. 2020. PMID: 32022257
CD146 mediates VEGF-induced melanoma cell extravasation through FAK activation.
Jouve N, Bachelier R, Despoix N, Blin MG, Matinzadeh MK, Poitevin S, Aurrand-Lions M, Fallague K, Bardin N, Blot-Chabaud M, Vely F, Dignat-George F, Leroyer AS. Jouve N, et al. Among authors: leroyer as. Int J Cancer. 2015 Jul 1;137(1):50-60. doi: 10.1002/ijc.29370. Epub 2014 Dec 11. Int J Cancer. 2015. PMID: 25449773
Targeting soluble CD146 with a neutralizing antibody inhibits vascularization, growth and survival of CD146-positive tumors.
Stalin J, Nollet M, Garigue P, Fernandez S, Vivancos L, Essaadi A, Muller A, Bachelier R, Foucault-Bertaud A, Fugazza L, Leroyer AS, Bardin N, Guillet B, Dignat-George F, Blot-Chabaud M. Stalin J, et al. Among authors: leroyer as. Oncogene. 2016 Oct 20;35(42):5489-5500. doi: 10.1038/onc.2016.83. Epub 2016 Apr 11. Oncogene. 2016. PMID: 27065325
Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform.
Stalin J, Harhouri K, Hubert L, Garrigue P, Nollet M, Essaadi A, Muller A, Foucault-Bertaud A, Bachelier R, Sabatier F, Pisano P, Peiretti F, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Stalin J, et al. Among authors: leroyer as. Cardiovasc Res. 2016 Aug 1;111(3):240-51. doi: 10.1093/cvr/cvw096. Epub 2016 May 11. Cardiovasc Res. 2016. PMID: 27170199
A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule.
Nollet M, Stalin J, Moyon A, Traboulsi W, Essaadi A, Robert S, Malissen N, Bachelier R, Daniel L, Foucault-Bertaud A, Gaudy-Marqueste C, Lacroix R, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Nollet M, et al. Among authors: leroyer as. Oncotarget. 2017 Nov 28;8(68):112283-112296. doi: 10.18632/oncotarget.22736. eCollection 2017 Dec 22. Oncotarget. 2017. PMID: 29348825 Free PMC article.
Stem cell properties of peripheral blood endothelial progenitors are stimulated by soluble CD146 via miR-21: potential use in autologous cell therapy.
Essaadi A, Nollet M, Moyon A, Stalin J, Simoncini S, Balasse L, Bertaud A, Bachelier R, Leroyer AS, Sarlon G, Guillet B, Dignat-George F, Bardin N, Blot-Chabaud M. Essaadi A, et al. Among authors: leroyer as. Sci Rep. 2018 Jun 20;8(1):9387. doi: 10.1038/s41598-018-27715-4. Sci Rep. 2018. PMID: 29925894 Free PMC article.
CD146 deficiency promotes plaque formation in a mouse model of atherosclerosis by enhancing RANTES secretion and leukocyte recruitment.
Blin MG, Bachelier R, Fallague K, Moussouni K, Aurrand-Lions M, Fernandez S, Guillet B, Robert S, Foucault-Bertaud A, Bardin N, Blot-Chabaud M, Dignat-George F, Leroyer AS. Blin MG, et al. Among authors: leroyer as. J Mol Cell Cardiol. 2019 May;130:76-87. doi: 10.1016/j.yjmcc.2019.03.017. Epub 2019 Mar 27. J Mol Cell Cardiol. 2019. PMID: 30928429
CD146 (Cluster of Differentiation 146).
Leroyer AS, Blin MG, Bachelier R, Bardin N, Blot-Chabaud M, Dignat-George F. Leroyer AS, et al. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1026-1033. doi: 10.1161/ATVBAHA.119.312653. Arterioscler Thromb Vasc Biol. 2019. PMID: 31070478 Free article. Review.
56 results