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eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
Valcikova B, Vadovicova N, Smolkova K, Zacpalova M, Krejci P, Lee S, Rauch J, Kolch W, von Kriegsheim A, Dorotikova A, Andrysik Z, Vichova R, Vacek O, Soucek K, Uldrijan S. Valcikova B, et al. Among authors: soucek k. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2321305121. doi: 10.1073/pnas.2321305121. Epub 2024 Oct 22. Proc Natl Acad Sci U S A. 2024. PMID: 39436655 Free PMC article.
Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization.
Verlande A, Krafčíková M, Potěšil D, Trantírek L, Zdráhal Z, Elkalaf M, Trnka J, Souček K, Rauch N, Rauch J, Kolch W, Uldrijan S. Verlande A, et al. Among authors: soucek k. EMBO Rep. 2018 Feb;19(2):320-336. doi: 10.15252/embr.201744524. Epub 2017 Dec 20. EMBO Rep. 2018. PMID: 29263201 Free PMC article.
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway.
Němec V, Hylsová M, Maier L, Flegel J, Sievers S, Ziegler S, Schröder M, Berger BT, Chaikuad A, Valčíková B, Uldrijan S, Drápela S, Souček K, Waldmann H, Knapp S, Paruch K. Němec V, et al. Among authors: soucek k. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066. doi: 10.1002/anie.201810312. Epub 2018 Dec 20. Angew Chem Int Ed Engl. 2019. PMID: 30569600
A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype.
Hýžďalová M, Procházková J, Strapáčová S, Svržková L, Vacek O, Fedr R, Andrysík Z, Hrubá E, Líbalová H, Kléma J, Topinka J, Mašek J, Souček K, Vondráček J, Machala M. Hýžďalová M, et al. Among authors: soucek k. Chemosphere. 2021 Jan;263:128126. doi: 10.1016/j.chemosphere.2020.128126. Epub 2020 Sep 10. Chemosphere. 2021. PMID: 33297115
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.
Radaszkiewicz T, Nosková M, Gömöryová K, Vondálová Blanářová O, Radaszkiewicz KA, Picková M, Víchová R, Gybeľ T, Kaiser K, Demková L, Kučerová L, Bárta T, Potěšil D, Zdráhal Z, Souček K, Bryja V. Radaszkiewicz T, et al. Among authors: soucek k. Elife. 2021 Oct 27;10:e65759. doi: 10.7554/eLife.65759. Elife. 2021. PMID: 34702444 Free PMC article.
TACSTD2 upregulation is an early reaction to lung infection.
Lenárt S, Lenárt P, Knopfová L, Kotasová H, Pelková V, Sedláková V, Vacek O, Pokludová J, Čan V, Šmarda J, Souček K, Hampl A, Beneš P. Lenárt S, et al. Among authors: soucek k. Sci Rep. 2022 Jun 10;12(1):9583. doi: 10.1038/s41598-022-13637-9. Sci Rep. 2022. PMID: 35688908 Free PMC article.
191 results