Chen M - Search Results

1

Activation of Gs signaling in mouse enteroendocrine K cells greatly improves obesity- and diabetes-related metabolic deficits.

Oteng AB, Liu L, Cui Y, Gavrilova O, Lu H, Chen M, Weinstein LS, Campbell JE, Lewis JE, Gribble FM, Reimann F, Wess J. Oteng AB, et al. Among authors: chen m. J Clin Invest. 2024 Oct 22;134(24):e182325. doi: 10.1172/JCI182325. J Clin Invest. 2024. PMID: 39436694 Free PMC article.

2

Gs(alpha) mutations and imprinting defects in human disease.

Weinstein LS, Chen M, Liu J. Weinstein LS, et al. Among authors: chen m. Ann N Y Acad Sci. 2002 Jun;968:173-97. doi: 10.1111/j.1749-6632.2002.tb04335.x. Ann N Y Acad Sci. 2002. PMID: 12119276 Review.

3

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.

Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS. Chen M, et al. J Clin Invest. 2005 Nov;115(11):3217-27. doi: 10.1172/JCI24196. Epub 2005 Oct 20. J Clin Invest. 2005. PMID: 16239968 Free PMC article.

4

Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.

Weinstein LS, Xie T, Zhang QH, Chen M. Weinstein LS, et al. Among authors: chen m. Pharmacol Ther. 2007 Aug;115(2):271-91. doi: 10.1016/j.pharmthera.2007.03.013. Epub 2007 Apr 21. Pharmacol Ther. 2007. PMID: 17588669 Free PMC article. Review.

5

Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.

Xie T, Chen M, Weinstein LS. Xie T, et al. Among authors: chen m. J Endocrinol. 2010 Sep;206(3):261-9. doi: 10.1677/JOE-10-0030. Epub 2010 Jun 11. J Endocrinol. 2010. PMID: 20543009 Free PMC article.

6

Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.

Chen M, Berger A, Kablan A, Zhang J, Gavrilova O, Weinstein LS. Chen M, et al. Endocrinology. 2012 Sep;153(9):4256-65. doi: 10.1210/en.2012-1113. Epub 2012 Jun 25. Endocrinology. 2012. PMID: 22733970 Free PMC article.

7

Gsα deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight.

Li YQ, Shrestha YB, Chen M, Chanturiya T, Gavrilova O, Weinstein LS. Li YQ, et al. Among authors: chen m. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):446-51. doi: 10.1073/pnas.1517142113. Epub 2015 Dec 28. Proc Natl Acad Sci U S A. 2016. PMID: 26712027 Free PMC article.

8

Gsα deficiency in the dorsomedial hypothalamus underlies obesity associated with Gsα mutations.

Chen M, Shrestha YB, Podyma B, Cui Z, Naglieri B, Sun H, Ho T, Wilson EA, Li YQ, Gavrilova O, Weinstein LS. Chen M, et al. J Clin Invest. 2017 Feb 1;127(2):500-510. doi: 10.1172/JCI88622. Epub 2016 Dec 19. J Clin Invest. 2017. PMID: 27991864 Free PMC article.

9

G_sα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling.

Chen M, Wilson EA, Cui Z, Sun H, Shrestha YB, Podyma B, Le CH, Naglieri B, Pacak K, Gavrilova O, Weinstein LS. Chen M, et al. Mol Metab. 2019 Jul;25:142-153. doi: 10.1016/j.molmet.2019.04.005. Epub 2019 Apr 12. Mol Metab. 2019. PMID: 31014927 Free PMC article.

10

In vivo metabolic effects after acute activation of skeletal muscle G_s signaling.

Meister J, Bone DBJ, Knudsen JR, Barella LF, Liu L, Lee R, Gavrilova O, Chen M, Weinstein LS, Kleinert M, Jensen TE, Wess J. Meister J, et al. Among authors: chen m. Mol Metab. 2022 Jan;55:101415. doi: 10.1016/j.molmet.2021.101415. Epub 2021 Dec 6. Mol Metab. 2022. PMID: 34883278 Free PMC article.

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