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Page 1
Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9.
Grosche P, Flyer AN, Gattlen R, Xu M, Golosov AA, Vera V, Pickett S, Brousseau ME, Chopra R, Clairmont KB, Koch A, Liu E, Reid P, Perry L, Yang L, Yang Q, Monovich LG. Grosche P, et al. Among authors: gattlen r. ChemMedChem. 2024 Dec 2;19(23):e202400208. doi: 10.1002/cmdc.202400208. Epub 2024 Oct 22. ChemMedChem. 2024. PMID: 39437016
Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction.
Jones M, Grosche P, Floersheimer A, André J, Gattlen R, Oser D, Tinchant J, Wille R, Chie-Leon B, Gerspacher M, Ertl P, Ostermann N, Altmann E, Manchado E, Vorherr T, Chène P. Jones M, et al. Among authors: gattlen r. Biochemistry. 2023 Apr 4;62(7):1321-1329. doi: 10.1021/acs.biochem.2c00690. Epub 2023 Mar 8. Biochemistry. 2023. PMID: 36883372
Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Brousseau ME, Clairmont KB, Spraggon G, Flyer AN, Golosov AA, Grosche P, Amin J, Andre J, Burdick D, Caplan S, Chen G, Chopra R, Ames L, Dubiel D, Fan L, Gattlen R, Kelly-Sullivan D, Koch AW, Lewis I, Li J, Liu E, Lubicka D, Marzinzik A, Nakajima K, Nettleton D, Ottl J, Pan M, Patel T, Perry L, Pickett S, Poirier J, Reid PC, Pelle X, Seepersaud M, Subramanian V, Vera V, Xu M, Yang L, Yang Q, Yu J, Zhu G, Monovich LG. Brousseau ME, et al. Among authors: gattlen r. Cell Chem Biol. 2022 Feb 17;29(2):249-258.e5. doi: 10.1016/j.chembiol.2021.08.012. Epub 2021 Sep 20. Cell Chem Biol. 2022. PMID: 34547225 Free article.