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Discovery of Truncated Cyclic Peptides Targeting an Induced-Fit Pocket on PCSK9.
Grosche P, Flyer AN, Gattlen R, Xu M, Golosov AA, Vera V, Pickett S, Brousseau ME, Chopra R, Clairmont KB, Koch A, Liu E, Reid P, Perry L, Yang L, Yang Q, Monovich LG. Grosche P, et al. Among authors: yang q, yang l. ChemMedChem. 2024 Dec 2;19(23):e202400208. doi: 10.1002/cmdc.202400208. Epub 2024 Oct 22. ChemMedChem. 2024. PMID: 39437016
Identification of a PCSK9-LDLR disruptor peptide with in vivo function.
Brousseau ME, Clairmont KB, Spraggon G, Flyer AN, Golosov AA, Grosche P, Amin J, Andre J, Burdick D, Caplan S, Chen G, Chopra R, Ames L, Dubiel D, Fan L, Gattlen R, Kelly-Sullivan D, Koch AW, Lewis I, Li J, Liu E, Lubicka D, Marzinzik A, Nakajima K, Nettleton D, Ottl J, Pan M, Patel T, Perry L, Pickett S, Poirier J, Reid PC, Pelle X, Seepersaud M, Subramanian V, Vera V, Xu M, Yang L, Yang Q, Yu J, Zhu G, Monovich LG. Brousseau ME, et al. Among authors: yang q, yang l. Cell Chem Biol. 2022 Feb 17;29(2):249-258.e5. doi: 10.1016/j.chembiol.2021.08.012. Epub 2021 Sep 20. Cell Chem Biol. 2022. PMID: 34547225 Free article.
Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Triglycerides in Humans.
Nakajima K, Chatelain R, Clairmont KB, Commerford R, Coppola GM, Daniels T, Forster CJ, Gilmore TA, Gong Y, Jain M, Kanter A, Kwak Y, Li J, Meyers CD, Neubert AD, Szklennik P, Tedesco V, Thompson J, Truong D, Yang Q, Hubbard BK, Serrano-Wu MH. Nakajima K, et al. Among authors: yang q. J Med Chem. 2017 Jun 8;60(11):4657-4664. doi: 10.1021/acs.jmedchem.7b00173. Epub 2017 May 24. J Med Chem. 2017. PMID: 28498655 Clinical Trial.
Intestinally Targeted Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors Robustly Suppress Postprandial Triglycerides.
Serrano-Wu MH, Coppola GM, Gong Y, Neubert AD, Chatelain R, Clairmont KB, Commerford R, Cosker T, Daniels T, Hou Y, Jain M, Juedes M, Li L, Mullarkey T, Rocheford E, Sung MJ, Tyler A, Yang Q, Yoon T, Hubbard BK. Serrano-Wu MH, et al. Among authors: yang q. ACS Med Chem Lett. 2012 Apr 4;3(5):411-5. doi: 10.1021/ml3000512. eCollection 2012 May 10. ACS Med Chem Lett. 2012. PMID: 24900485 Free PMC article.
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