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Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia.
Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, Hersh LB, Porter NM, Wilcock DM, Murphy MP. Niedowicz DM, et al. Among authors: powell dk. Acta Neuropathol Commun. 2014 Jun 10;2:64. doi: 10.1186/2051-5960-2-64. Acta Neuropathol Commun. 2014. PMID: 24916066 Free PMC article.
Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain").
Keeney JTR, Ren X, Warrier G, Noel T, Powell DK, Brelsfoard JM, Sultana R, Saatman KE, Clair DKS, Butterfield DA. Keeney JTR, et al. Among authors: powell dk. Oncotarget. 2018 Jul 13;9(54):30324-30339. doi: 10.18632/oncotarget.25718. eCollection 2018 Jul 13. Oncotarget. 2018. PMID: 30100992 Free PMC article.
Tacrolimus Protects against Age-Associated Microstructural Changes in the Beagle Brain.
Radhakrishnan H, Ubele MF, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. Radhakrishnan H, et al. Among authors: powell dk. J Neurosci. 2021 Jun 9;41(23):5124-5133. doi: 10.1523/JNEUROSCI.0361-21.2021. Epub 2021 May 5. J Neurosci. 2021. PMID: 33952632 Free PMC article.
Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
Sompol P, Gollihue JL, Weiss BE, Lin RL, Case SL, Kraner SD, Weekman EM, Gant JC, Rogers CB, Niedowicz DM, Sudduth TL, Powell DK, Lin AL, Nelson PT, Thibault O, Wilcock DM, Norris CM. Sompol P, et al. Among authors: powell dk. J Neurosci. 2023 Mar 8;43(10):1797-1813. doi: 10.1523/JNEUROSCI.1333-22.2023. Epub 2023 Feb 6. J Neurosci. 2023. PMID: 36746627 Free PMC article.
Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles.
Noche JA, Radhakrishnan H, Ubele MF, Boaz K, Mefford JL, Jones ED, van Rooyen HY, Perpich JA, McCarty K, Meacham B, Smiley J, Bembenek Bailey SA, Puskás LG, Powell DK, Sordo L, Phelan MJ, Norris CM, Head E, Stark CEL. Noche JA, et al. Among authors: powell dk. J Neurosci. 2024 May 15;44(20):e2366232024. doi: 10.1523/JNEUROSCI.2366-23.2024. J Neurosci. 2024. PMID: 38561226 Free PMC article.
A small molecule p38α MAPK inhibitor, MW150, attenuates behavioral deficits and neuronal dysfunction in a mouse model of mixed amyloid and vascular pathologies.
Frazier HN, Braun DJ, Bailey CS, Coleman MJ, Davis VA, Dundon SR, McLouth CJ, Muzyk HC, Powell DK, Rogers CB, Roy SM, Van Eldik LJ. Frazier HN, et al. Among authors: powell dk. Brain Behav Immun Health. 2024 Jul 23;40:100826. doi: 10.1016/j.bbih.2024.100826. eCollection 2024 Oct. Brain Behav Immun Health. 2024. PMID: 39161874 Free PMC article.
Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.
Sordo L, Ubele MF, Boaz KA, Mefford JL, Jones ED, McCarty KL, van Rooyen HY, Smiley J, Bembenek Bailey SA, Perpich JA, Meacham B, Powell DK, Bresch F, Crump JW, Phelan MJ, Noche JA, Stark CE, Puskás LG, Norris CM, Head E. Sordo L, et al. Among authors: powell dk. Neurobiol Aging. 2025 Feb;146:1-14. doi: 10.1016/j.neurobiolaging.2024.11.003. Epub 2024 Nov 10. Neurobiol Aging. 2025. PMID: 39547056
99 results