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Page 1
PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.
Yang Y, Jayaprakash D, Jhujh SS, Reynolds JJ, Chen S, Gao Y, Anand JR, Mutter-Rottmayer E, Ariel P, An J, Cheng X, Pearce KH, Blanchet SA, Nandakumar N, Zhou P, Fradet-Turcotte A, Stewart GS, Vaziri C. Yang Y, et al. Among authors: jhujh ss. Nucleic Acids Res. 2024 Nov 27;52(21):13019-13035. doi: 10.1093/nar/gkae918. Nucleic Acids Res. 2024. PMID: 39445802 Free PMC article.
USP37 prevents premature disassembly of stressed replisomes by TRAIP.
Kochenova OV, D'Alessandro G, Pilger D, Schmid E, Richards SL, Garcia MR, Jhujh SS, Voigt A, Gupta V, Carnie CJ, Wu RA, Gueorguieva N, Stewart GS, Walter JC, Jackson SP. Kochenova OV, et al. Among authors: jhujh ss. bioRxiv [Preprint]. 2024 Sep 4:2024.09.03.611025. doi: 10.1101/2024.09.03.611025. bioRxiv. 2024. PMID: 39282314 Free PMC article. Preprint.
The structural mechanism of dimeric DONSON in replicative helicase activation.
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A. Cvetkovic MA, et al. Among authors: jhujh ss. Mol Cell. 2023 Nov 16;83(22):4017-4031.e9. doi: 10.1016/j.molcel.2023.09.029. Epub 2023 Oct 10. Mol Cell. 2023. PMID: 37820732 Free PMC article.
Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.
Grange LJ, Reynolds JJ, Ullah F, Isidor B, Shearer RF, Latypova X, Baxley RM, Oliver AW, Ganesh A, Cooke SL, Jhujh SS, McNee GS, Hollingworth R, Higgs MR, Natsume T, Khan T, Martos-Moreno GÁ, Chupp S, Mathew CG, Parry D, Simpson MA, Nahavandi N, Yüksel Z, Drasdo M, Kron A, Vogt P, Jonasson A, Seth SA, Gonzaga-Jauregui C, Brigatti KW, Stegmann APA, Kanemaki M, Josifova D, Uchiyama Y, Oh Y, Morimoto A, Osaka H, Ammous Z, Argente J, Matsumoto N, Stumpel CTRM, Taylor AMR, Jackson AP, Bielinsky AK, Mailand N, Le Caignec C, Davis EE, Stewart GS. Grange LJ, et al. Among authors: jhujh ss. Nat Commun. 2022 Nov 4;13(1):6664. doi: 10.1038/s41467-022-34349-8. Nat Commun. 2022. PMID: 36333305 Free PMC article.
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GM, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan GL, Roukos V, Harel T, Brosh RM Jr, Stewart GS. Abu-Libdeh B, et al. Among authors: jhujh ss. J Clin Invest. 2022 Mar 1;132(5):e147301. doi: 10.1172/JCI147301. J Clin Invest. 2022. PMID: 35025765 Free PMC article.