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PCNA-binding activity separates RNF168 functions in DNA replication and DNA double-stranded break signaling.
Yang Y, Jayaprakash D, Jhujh SS, Reynolds JJ, Chen S, Gao Y, Anand JR, Mutter-Rottmayer E, Ariel P, An J, Cheng X, Pearce KH, Blanchet SA, Nandakumar N, Zhou P, Fradet-Turcotte A, Stewart GS, Vaziri C. Yang Y, et al. Among authors: stewart gs. Nucleic Acids Res. 2024 Nov 27;52(21):13019-13035. doi: 10.1093/nar/gkae918. Nucleic Acids Res. 2024. PMID: 39445802 Free PMC article.
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R. Bohgaki M, et al. Among authors: stewart gs. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9. Proc Natl Acad Sci U S A. 2013. PMID: 24324146 Free PMC article.
RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
Abu-Libdeh B, Jhujh SS, Dhar S, Sommers JA, Datta A, Longo GM, Grange LJ, Reynolds JJ, Cooke SL, McNee GS, Hollingworth R, Woodward BL, Ganesh AN, Smerdon SJ, Nicolae CM, Durlacher-Betzer K, Molho-Pessach V, Abu-Libdeh A, Meiner V, Moldovan GL, Roukos V, Harel T, Brosh RM Jr, Stewart GS. Abu-Libdeh B, et al. Among authors: stewart gs. J Clin Invest. 2022 Mar 1;132(5):e147301. doi: 10.1172/JCI147301. J Clin Invest. 2022. PMID: 35025765 Free PMC article.
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
Zlatanou A, Sabbioneda S, Miller ES, Greenwalt A, Aggathanggelou A, Maurice MM, Lehmann AR, Stankovic T, Reverdy C, Colland F, Vaziri C, Stewart GS. Zlatanou A, et al. Among authors: stewart gs. Oncogene. 2016 Feb 25;35(8):965-76. doi: 10.1038/onc.2015.149. Epub 2015 May 11. Oncogene. 2016. PMID: 25961918
232 results