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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Sajadi MM, Abbasi A, Tehrani ZR, Siska C, Clark R, Chi W, Seaman MS, Mielke D, Wagh K, Liu Q, Jumpa T, Ketchem RR, Nguyen DN, Tolbert WD, Pierce BG, Atkinson B, Deming D, Sprague M, Asakawa A, Ferrer D, Dunn Y, Calvillo S, Yin R, Guest JD, Korber B, Mayer BT, Sato AH, Ouyang X, Foulke S, Habibzadeh P, Karimi M, Aslanabadi A, Hojabri M, Saadat S, Zareidoodeji R, Kędzior M, Pozharski E, Heredia A, Montefiori D, Ferrari G, Pazgier M, Lewis GK, Jardine JG, Lusso P, DeVico A. Sajadi MM, et al. Among authors: clark r. bioRxiv [Preprint]. 2024 Oct 17:2024.10.14.618178. doi: 10.1101/2024.10.14.618178. bioRxiv. 2024. PMID: 39464103 Free PMC article. Preprint.
Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity.
Kerwin BA, Bennett C, Brodsky Y, Clark R, Floyd JA, Gillespie A, Mayer BT, McClure M, Siska C, Seaman MS, Seaton KE, Shaver J, Tomaras GD, Yates NL, Ketchem RR. Kerwin BA, et al. Among authors: clark r. J Pharm Sci. 2020 Jan;109(1):233-246. doi: 10.1016/j.xphs.2019.07.009. Epub 2019 Jul 23. J Pharm Sci. 2020. PMID: 31348937 Free PMC article.
AI-based antibody discovery platform identifies novel, diverse, and pharmacologically active therapeutic antibodies against multiple SARS-CoV-2 strains.
Loomis CM, Lahlali T, Van Citters D, Sprague M, Neveu G, Somody L, Siska CC, Deming D, Asakawa AJ, Amimeur T, Shaver JM, Carbonelle C, Ketchem RR, Alam A, Clark RH. Loomis CM, et al. Among authors: clark rh. Antib Ther. 2024 Sep 26;7(4):307-323. doi: 10.1093/abt/tbae025. eCollection 2024 Oct. Antib Ther. 2024. PMID: 39381135 Free PMC article.
Urogynecologic Care for Women Who Are Incarcerated.
Clark RA, Landis Lewis D, Hong CX. Clark RA, et al. Urogynecology (Phila). 2024 Oct 9. doi: 10.1097/SPV.0000000000001590. Online ahead of print. Urogynecology (Phila). 2024. PMID: 39733287
7,394 results