Ho TCS - Search Results

1

Identification and characterization of thiamine analogs with antiplasmodial activity.

Fathoni I, Ho TCS, Chan AHY, Leeper FJ, Matuschewski K, Saliba KJ. Fathoni I, et al. Among authors: ho tcs. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0109624. doi: 10.1128/aac.01096-24. Epub 2024 Oct 29. Antimicrob Agents Chemother. 2024. PMID: 39470204

2

Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity.

Chan AHY, Fathoni I, Ho TCS, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. RSC Med Chem. 2022 Jun 7;13(7):817-821. doi: 10.1039/d2md00085g. eCollection 2022 Jul 20. RSC Med Chem. 2022. PMID: 35919337 Free PMC article.

3

Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase.

Chan AHY, Ho TCS, Agyei-Owusu K, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. Org Biomol Chem. 2022 Nov 23;20(45):8855-8858. doi: 10.1039/d2ob01819e. Org Biomol Chem. 2022. PMID: 36326656

4

Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis.

Chan AHY, Ho TCS, Parle DR, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. Org Biomol Chem. 2023 Feb 22;21(8):1755-1763. doi: 10.1039/d2ob02272a. Org Biomol Chem. 2023. PMID: 36723268

5

Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity.

Chan AHY, Fathoni I, Ho TCS, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. RSC Med Chem. 2022 Dec 14;14(1):190. doi: 10.1039/d2md90043b. eCollection 2023 Jan 25. RSC Med Chem. 2022. PMID: 36755638 Free PMC article.

6

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues.

Chan AHY, Ho TCS, Fathoni I, Pope R, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. ACS Med Chem Lett. 2023 Apr 11;14(5):621-628. doi: 10.1021/acsmedchemlett.3c00047. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197459 Free PMC article.

7

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes.

Chan AHY, Ho TCS, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. Org Biomol Chem. 2023 Aug 16;21(32):6531-6536. doi: 10.1039/d3ob00884c. Org Biomol Chem. 2023. PMID: 37522836

8

Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase.

Chan AHY, Ho TCS, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. Bioorg Med Chem Lett. 2024 Jan 15;98:129571. doi: 10.1016/j.bmcl.2023.129571. Epub 2023 Nov 29. Bioorg Med Chem Lett. 2024. PMID: 38036274 Free article.

9

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes.

Chan AHY, Ho TCS, Fathoni I, Hamid R, Hirsch AKH, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: ho tcs. RSC Med Chem. 2024 Apr 2;15(5):1773-1781. doi: 10.1039/d4md00083h. eCollection 2024 May 22. RSC Med Chem. 2024. PMID: 38784473 Free PMC article.

10

Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding.

Ho TCS, Chan AHY, Leeper FJ. Ho TCS, et al. ACS Omega. 2024 Sep 30;9(41):42245-42252. doi: 10.1021/acsomega.4c04594. eCollection 2024 Oct 15. ACS Omega. 2024. PMID: 39431096 Free PMC article.

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