Leeper FJ - Search Results

1

Identification and characterization of thiamine analogs with antiplasmodial activity.

Fathoni I, Ho TCS, Chan AHY, Leeper FJ, Matuschewski K, Saliba KJ. Fathoni I, et al. Among authors: leeper fj. Antimicrob Agents Chemother. 2024 Dec 5;68(12):e0109624. doi: 10.1128/aac.01096-24. Epub 2024 Oct 29. Antimicrob Agents Chemother. 2024. PMID: 39470204

2

Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity.

Chan AHY, Fathoni I, Ho TCS, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. RSC Med Chem. 2022 Dec 14;14(1):190. doi: 10.1039/d2md90043b. eCollection 2023 Jan 25. RSC Med Chem. 2022. PMID: 36755638 Free PMC article.

3

Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase.

Chan AHY, Ho TCS, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. Bioorg Med Chem Lett. 2024 Jan 15;98:129571. doi: 10.1016/j.bmcl.2023.129571. Epub 2023 Nov 29. Bioorg Med Chem Lett. 2024. PMID: 38036274 Free article.

4

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.

Chan AHY, Ho TCS, Irfan R, Hamid RAA, Rudge ES, Iqbal A, Turner A, Hirsch AKH, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. Bioorg Chem. 2023 Sep;138:106602. doi: 10.1016/j.bioorg.2023.106602. Epub 2023 May 10. Bioorg Chem. 2023. PMID: 37201323 Free article.

5

Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding.

Ho TCS, Chan AHY, Leeper FJ. Ho TCS, et al. Among authors: leeper fj. ACS Omega. 2024 Sep 30;9(41):42245-42252. doi: 10.1021/acsomega.4c04594. eCollection 2024 Oct 15. ACS Omega. 2024. PMID: 39431096 Free PMC article.

6

Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis.

Oliveira GS, Dos S Bury P, Huang F, Li Y, Araújo NC, Zhou J, Sun Y, Leeper FJ, Leadlay PF, Dias MVB. Oliveira GS, et al. Among authors: leeper fj. ACS Chem Biol. 2024 Sep 20;19(9):2002-2011. doi: 10.1021/acschembio.4c00334. Epub 2024 Aug 29. ACS Chem Biol. 2024. PMID: 39207862 Free PMC article.

7

Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes.

Chan AHY, Ho TCS, Fathoni I, Hamid R, Hirsch AKH, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. RSC Med Chem. 2024 Apr 2;15(5):1773-1781. doi: 10.1039/d4md00083h. eCollection 2024 May 22. RSC Med Chem. 2024. PMID: 38784473 Free PMC article.

8

Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes.

Chan AHY, Ho TCS, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. Org Biomol Chem. 2023 Aug 16;21(32):6531-6536. doi: 10.1039/d3ob00884c. Org Biomol Chem. 2023. PMID: 37522836

9

Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues.

Chan AHY, Ho TCS, Fathoni I, Pope R, Saliba KJ, Leeper FJ. Chan AHY, et al. Among authors: leeper fj. ACS Med Chem Lett. 2023 Apr 11;14(5):621-628. doi: 10.1021/acsmedchemlett.3c00047. eCollection 2023 May 11. ACS Med Chem Lett. 2023. PMID: 37197459 Free PMC article.

10

Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module.

Murphy AC, Corney M, Monson RE, Matilla MA, Salmond GPC, Leeper FJ. Murphy AC, et al. Among authors: leeper fj. ACS Chem Biol. 2023 May 19;18(5):1148-1157. doi: 10.1021/acschembio.2c00947. Epub 2023 Apr 17. ACS Chem Biol. 2023. PMID: 37068480 Free PMC article.

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