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Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase.
Jumde RP, Guardigni M, Gierse RM, Alhayek A, Zhu D, Hamid Z, Johannsen S, Elgaher WAM, Neusens PJ, Nehls C, Haupenthal J, Reiling N, Hirsch AKH. Jumde RP, et al. Among authors: haupenthal j. Chem Sci. 2021 Apr 28;12(22):7775-7785. doi: 10.1039/d1sc00330e. Chem Sci. 2021. PMID: 34168831 Free PMC article.
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinović J, Kany AM, Haupenthal J, Köhnke J, Hartmann RW, Hirsch AKH. Kaya C, et al. Among authors: haupenthal j. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112295. doi: 10.1002/anie.202112295. Epub 2021 Dec 13. Angew Chem Int Ed Engl. 2022. PMID: 34762767 Free PMC article.
69 results