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Discovery of colchicine aryne cycloadduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases in breast cancer cells.
Iqbal Lone W, Chand J, Kumar P, Garg Y, Ahmed Z, Mukherjee D, Goswami A, Momo H Anãl J. Iqbal Lone W, et al. Among authors: kumar p. Bioorg Chem. 2024 Sep;150:107581. doi: 10.1016/j.bioorg.2024.107581. Epub 2024 Jun 20. Bioorg Chem. 2024. PMID: 38908129
Controlled synthesis of CD2H-ketones.
Kumar P, Pattison G. Kumar P, et al. Chem Commun (Camb). 2024 Nov 5. doi: 10.1039/d4cc04819a. Online ahead of print. Chem Commun (Camb). 2024. PMID: 39499550
The cyclin-G associated kinase (GAK) is a novel mitotic kinase and therapeutic target in diffuse large B-cell lymphoma.
Lightfuss OB, Kumar P, Li L, Shastri T, Newsam AD, Manara P, Alaoui AY, Parets DEH, Younes PA, Chahar D, Arumov A, Coughlin CA, Williams IP, Fattakhov N, Martinez AB, Landgren O, Schurer SC, Lemmon V, Maura F, Bilbao D, Feng Y, Al-Ali H, Schatz JH. Lightfuss OB, et al. Among authors: kumar p. bioRxiv [Preprint]. 2024 Oct 26:2024.10.21.619489. doi: 10.1101/2024.10.21.619489. bioRxiv. 2024. PMID: 39484514 Free PMC article. Preprint.
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