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Page 1
Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis.
Vega-Letter AM, García-Guerrero C, Yantén-Fuentes L, Pradenas C, Herrera-Luna Y, Lara-Barba E, Bustamante-Barrientos FA, Rojas M, Araya MJ, Jeraldo N, Aros C, Troncoso F, Poblete D, Court A, Ortloff A, Barraza J, Velarde F, Farkas C, Carril C, Luque-Campos N, Almarza G, Barahona M, Matas J, Cereceda L, Lorca R, Toledo J, Oyarce K, Vernal R, Caicedo A, Del Campo A, Hidalgo Y, Elizondo-Vega R, Djouad F, Khoury M, Figueroa FE, Luz-Crawford P. Vega-Letter AM, et al. Among authors: pradenas c. J Transl Med. 2025 Jan 7;23(1):26. doi: 10.1186/s12967-024-05945-7. J Transl Med. 2025. PMID: 39773289
Mitochondrial transfer balances cell redox, energy and metabolic homeostasis in the osteoarthritic chondrocyte preserving cartilage integrity.
Court AC, Vega-Letter AM, Parra-Crisóstomo E, Velarde F, García C, Ortloff A, Vernal R, Pradenas C, Luz-Crawford P, Khoury M, Figueroa FE. Court AC, et al. Among authors: pradenas c. Theranostics. 2024 Oct 7;14(17):6471-6486. doi: 10.7150/thno.96723. eCollection 2024. Theranostics. 2024. PMID: 39479450 Free PMC article.
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells.
Pradenas C, Luque-Campos N, Oyarce K, Contreras-Lopez R, Bustamante-Barrientos FA, Bustos A, Galvez-Jiron F, Araya MJ, Asencio C, Lagos R, Herrera-Luna Y, Abba Moussa D, Hill CN, Lara-Barba E, Altamirano C, Ortloff A, Hidalgo-Fadic Y, Vega-Letter AM, García-Robles MLÁ, Djouad F, Luz-Crawford P, Elizondo-Vega R. Pradenas C, et al. Stem Cell Res Ther. 2023 Nov 19;14(1):335. doi: 10.1186/s13287-023-03549-4. Stem Cell Res Ther. 2023. PMID: 37981698 Free PMC article.
Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells.
Bustamante-Barrientos FA, Luque-Campos N, Araya MJ, Lara-Barba E, de Solminihac J, Pradenas C, Molina L, Herrera-Luna Y, Utreras-Mendoza Y, Elizondo-Vega R, Vega-Letter AM, Luz-Crawford P. Bustamante-Barrientos FA, et al. Among authors: pradenas c. J Transl Med. 2023 Sep 9;21(1):613. doi: 10.1186/s12967-023-04493-w. J Transl Med. 2023. PMID: 37689642 Free PMC article. Review.
Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment.
Lara-Barba E, Araya MJ, Hill CN, Bustamante-Barrientos FA, Ortloff A, García C, Galvez-Jiron F, Pradenas C, Luque-Campos N, Maita G, Elizondo-Vega R, Djouad F, Vega-Letter AM, Luz-Crawford P. Lara-Barba E, et al. Among authors: pradenas c. Front Immunol. 2021 Nov 1;12:768771. doi: 10.3389/fimmu.2021.768771. eCollection 2021. Front Immunol. 2021. PMID: 34790203 Free PMC article. Review.
The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming.
Luque-Campos N, Bustamante-Barrientos FA, Pradenas C, García C, Araya MJ, Bohaud C, Contreras-López R, Elizondo-Vega R, Djouad F, Luz-Crawford P, Vega-Letter AM. Luque-Campos N, et al. Among authors: pradenas c. Front Immunol. 2021 Jun 4;12:624746. doi: 10.3389/fimmu.2021.624746. eCollection 2021. Front Immunol. 2021. PMID: 34149687 Free PMC article. Review.
The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential.
Contreras-Lopez R, Elizondo-Vega R, Luque-Campos N, Torres MJ, Pradenas C, Tejedor G, Paredes-Martínez MJ, Vega-Letter AM, Campos-Mora M, Rigual-Gonzalez Y, Oyarce K, Salgado M, Jorgensen C, Khoury M, Garcia-Robles MLÁ, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. Among authors: pradenas c. Theranostics. 2021 Jan 1;11(1):445-460. doi: 10.7150/thno.51631. eCollection 2021. Theranostics. 2021. PMID: 33391485 Free PMC article.
PPARβ/δ-dependent MSC metabolism determines their immunoregulatory properties.
Contreras-Lopez RA, Elizondo-Vega R, Torres MJ, Vega-Letter AM, Luque-Campos N, Paredes-Martinez MJ, Pradenas C, Tejedor G, Oyarce K, Salgado M, Jorgensen C, Khoury M, Kronke G, Garcia-Robles MA, Altamirano C, Luz-Crawford P, Djouad F. Contreras-Lopez RA, et al. Among authors: pradenas c. Sci Rep. 2020 Jul 10;10(1):11423. doi: 10.1038/s41598-020-68347-x. Sci Rep. 2020. PMID: 32651456 Free PMC article.
HIF1α-dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions.
Contreras-Lopez R, Elizondo-Vega R, Paredes MJ, Luque-Campos N, Torres MJ, Tejedor G, Vega-Letter AM, Figueroa-Valdés A, Pradenas C, Oyarce K, Jorgensen C, Khoury M, Garcia-Robles MLA, Altamirano C, Djouad F, Luz-Crawford P. Contreras-Lopez R, et al. Among authors: pradenas c. FASEB J. 2020 Jun;34(6):8250-8264. doi: 10.1096/fj.201902232R. Epub 2020 Apr 25. FASEB J. 2020. PMID: 32333618