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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Williams A, et al. Among authors: fleming a. Nat Chem Biol. 2008 May;4(5):295-305. doi: 10.1038/nchembio.79. Nat Chem Biol. 2008. PMID: 18391949 Free PMC article.
PICALM modulates autophagy activity and tau accumulation.
Moreau K, Fleming A, Imarisio S, Lopez Ramirez A, Mercer JL, Jimenez-Sanchez M, Bento CF, Puri C, Zavodszky E, Siddiqi F, Lavau CP, Betton M, O'Kane CJ, Wechsler DS, Rubinsztein DC. Moreau K, et al. Among authors: fleming a. Nat Commun. 2014 Sep 22;5:4998. doi: 10.1038/ncomms5998. Nat Commun. 2014. PMID: 25241929 Free PMC article.
Compromised autophagy and neurodegenerative diseases.
Menzies FM, Fleming A, Rubinsztein DC. Menzies FM, et al. Among authors: fleming a. Nat Rev Neurosci. 2015 Jun;16(6):345-57. doi: 10.1038/nrn3961. Nat Rev Neurosci. 2015. PMID: 25991442 Review.
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, Bassett A, Karran E, Miller BL, Fleming A, Rubinsztein DC. Siddiqi FH, et al. Among authors: fleming a. Nat Commun. 2019 Apr 18;10(1):1817. doi: 10.1038/s41467-019-09494-2. Nat Commun. 2019. PMID: 31000720 Free PMC article.
Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, Bassett A, Karran E, Miller BL, Fleming A, Rubinsztein DC. Siddiqi FH, et al. Among authors: fleming a. Nat Commun. 2019 Jun 4;10(1):2530. doi: 10.1038/s41467-019-10536-y. Nat Commun. 2019. PMID: 31164655 Free PMC article.
Autophagy in Neuronal Development and Plasticity.
Fleming A, Rubinsztein DC. Fleming A, et al. Trends Neurosci. 2020 Oct;43(10):767-779. doi: 10.1016/j.tins.2020.07.003. Epub 2020 Aug 13. Trends Neurosci. 2020. PMID: 32800535 Review.
1,490 results