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Page 1
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Tuck BJ, Miller LVC, Katsinelos T, Smith AE, Wilson EL, Keeling S, Cheng S, Vaysburd MJ, Knox C, Tredgett L, Metzakopian E, James LC, McEwan WA. Tuck BJ, et al. Among authors: keeling s. Cell Rep. 2022 May 3;39(5):110776. doi: 10.1016/j.celrep.2022.110776. Cell Rep. 2022. PMID: 35508140 Free PMC article.
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.
Mukadam AS, Miller LVC, Smith AE, Vaysburd M, Sakya SA, Sanford S, Keeling S, Tuck BJ, Katsinelos T, Green C, Skov L, Kaalund SS, Foss S, Mayes K, O'Connell K, Wing M, Knox C, Banbury J, Avezov E, Rowe JB, Goedert M, Andersen JT, James LC, McEwan WA. Mukadam AS, et al. Among authors: keeling s. Science. 2023 Mar 31;379(6639):1336-1341. doi: 10.1126/science.abn1366. Epub 2023 Mar 30. Science. 2023. PMID: 36996217 Free PMC article.
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
Dimou E, Katsinelos T, Meisl G, Tuck BJ, Keeling S, Smith AE, Hidari E, Lam JYL, Burke M, Lövestam S, Ranasinghe RT, McEwan WA, Klenerman D. Dimou E, et al. Among authors: keeling s. Cell Rep. 2023 Jul 25;42(7):112725. doi: 10.1016/j.celrep.2023.112725. Epub 2023 Jul 1. Cell Rep. 2023. PMID: 37393617 Free PMC article.
Aggregate-selective removal of pathological tau by clustering-activated degraders.
Benn J, Cheng S, Keeling S, Smith AE, Vaysburd MJ, Böken D, Miller LVC, Katsinelos T, Franco C, Dupré E, Danis C, Landrieu I, Buée L, Klenerman D, James LC, McEwan WA. Benn J, et al. Among authors: keeling s. Science. 2024 Aug 30;385(6712):1009-1016. doi: 10.1126/science.adp5186. Epub 2024 Aug 29. Science. 2024. PMID: 39208111 Free PMC article.
Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons.
Marvian AT, Strauss T, Tang Q, Tuck BJ, Keeling S, Rüdiger D, Mirzazadeh Dizaji N, Mohammad-Beigi H, Nuscher B, Chakraborty P, Sutherland DS, McEwan WA, Köglsperger T, Zahler S, Zweckstetter M, Lichtenthaler SF, Wurst W, Schwarz S, Höglinger G. Marvian AT, et al. Among authors: keeling s. Mol Neurodegener. 2024 Dec 31;19(1):100. doi: 10.1186/s13024-024-00786-w. Mol Neurodegener. 2024. PMID: 39736627 Free PMC article.
Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain.
Maksymowych WP, Carmona R, Weber U, Aydin SZ, Yeung J, Reis J, Masetto A, Rohekar S, Mosher D, Zouzina O, Martin L, Keeling SO, Paschke J, Dadashova R, Carapellucci A, Wichuk S, Lambert RG, Chan J. Maksymowych WP, et al. Among authors: keeling so. Arthritis Rheumatol. 2025 Jan;77(1):47-58. doi: 10.1002/art.42967. Epub 2024 Sep 3. Arthritis Rheumatol. 2025. PMID: 39107875 Free PMC article.
218 results