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Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Kristensen JM, Kjøbsted R, Larsen TJ, Carl CS, Hingst JR, Onslev J, Birk JB, Thorup A, Steenberg DE, Knudsen JR, Henriksen NS, Needham EJ, Halling JF, Gudiksen A, Rundsten CF, Hanghøj KE, Stinson SE, Hoier B, Hansen CC, Jensen TE, Hellsten Y, Pilegaard H, Grarup N, Olesen J, Humphrey SJ, James DE, Pedersen ML, Richter EA, Hansen T, Jørgensen ME, Wojtaszewski JFP. Kristensen JM, et al. Among authors: grarup n. Nat Metab. 2024 Dec;6(12):2254-2266. doi: 10.1038/s42255-024-01153-1. Epub 2024 Oct 31. Nat Metab. 2024. PMID: 39482542 Free PMC article.
The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.
Grarup N, Andreasen CH, Andersen MK, Albrechtsen A, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Schmitz O, Hansen T, Pedersen O. Grarup N, et al. J Clin Endocrinol Metab. 2008 Jun;93(6):2294-9. doi: 10.1210/jc.2007-2815. Epub 2008 Mar 25. J Clin Endocrinol Metab. 2008. PMID: 18364377
Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
Grarup N, Andersen G, Krarup NT, Albrechtsen A, Schmitz O, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen O. Grarup N, et al. Diabetes. 2008 Sep;57(9):2534-40. doi: 10.2337/db08-0436. Epub 2008 Jun 20. Diabetes. 2008. PMID: 18567820 Free PMC article.
Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle.
Ribel-Madsen R, Poulsen P, Holmkvist J, Mortensen B, Grarup N, Friedrichsen M, Jørgensen T, Lauritzen T, Wojtaszewski JF, Pedersen O, Hansen T, Vaag A. Ribel-Madsen R, et al. Among authors: grarup n. Diabetes. 2010 Apr;59(4):1108-12. doi: 10.2337/db09-1359. Epub 2010 Jan 27. Diabetes. 2010. PMID: 20107106 Free PMC article.
329 results