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Skeletal muscle from TBC1D4 p.Arg684Ter variant carriers is severely insulin resistant but exhibits normal metabolic responses during exercise.
Kristensen JM, Kjøbsted R, Larsen TJ, Carl CS, Hingst JR, Onslev J, Birk JB, Thorup A, Steenberg DE, Knudsen JR, Henriksen NS, Needham EJ, Halling JF, Gudiksen A, Rundsten CF, Hanghøj KE, Stinson SE, Hoier B, Hansen CC, Jensen TE, Hellsten Y, Pilegaard H, Grarup N, Olesen J, Humphrey SJ, James DE, Pedersen ML, Richter EA, Hansen T, Jørgensen ME, Wojtaszewski JFP. Kristensen JM, et al. Among authors: james de. Nat Metab. 2024 Dec;6(12):2254-2266. doi: 10.1038/s42255-024-01153-1. Epub 2024 Oct 31. Nat Metab. 2024. PMID: 39482542 Free PMC article.
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Humphrey SJ, James DE. Humphrey SJ, et al. Among authors: james de. Sci Signal. 2012 May 8;5(223):pe20. doi: 10.1126/scisignal.2003085. Sci Signal. 2012. PMID: 22569332
Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.
Kleinert M, Sylow L, Fazakerley DJ, Krycer JR, Thomas KC, Oxbøll AJ, Jordy AB, Jensen TE, Yang G, Schjerling P, Kiens B, James DE, Ruegg MA, Richter EA. Kleinert M, et al. Among authors: james de. Mol Metab. 2014 Jun 27;3(6):630-41. doi: 10.1016/j.molmet.2014.06.004. eCollection 2014 Sep. Mol Metab. 2014. PMID: 25161886 Free PMC article.
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