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Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice.
Delfinis LJ, Khajehzadehshoushtar S, Flewwelling LD, Andrews NJ, Garibotti MC, Gandhi S, Brahmbhatt AN, Morris BA, Garlisi B, Lauks S, Aitken C, Tsitkanou S, Simpson JA, Greene NP, Cheng AJ, Petrik J, Perry CGR. Delfinis LJ, et al. Among authors: tsitkanou s. bioRxiv [Preprint]. 2024 Oct 25:2024.10.22.619751. doi: 10.1101/2024.10.22.619751. bioRxiv. 2024. PMID: 39484418 Free PMC article. Preprint.
Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice.
Tsitkanou S, Morena da Silva F, Cabrera AR, Schrems ER, Muhyudin R, Koopmans PJ, Khadgi S, Lim S, Delfinis LJ, Washington TA, Murach KA, Perry CGR, Greene NP. Tsitkanou S, et al. Am J Physiol Cell Physiol. 2024 Nov 1;327(5):C1308-C1322. doi: 10.1152/ajpcell.00497.2024. Epub 2024 Sep 30. Am J Physiol Cell Physiol. 2024. PMID: 39344417
Females display relatively preserved muscle quality compared with males during the onset and early stages of C26-induced cancer cachexia.
Cabrera AR, Deaver JW, Lim S, Morena da Silva F, Schrems ER, Saling LW, Tsitkanou S, Rosa-Caldwell ME, Wiggs MP, Washington TA, Greene NP. Cabrera AR, et al. Among authors: tsitkanou s. J Appl Physiol (1985). 2023 Sep 1;135(3):655-672. doi: 10.1152/japplphysiol.00196.2023. Epub 2023 Aug 3. J Appl Physiol (1985). 2023. PMID: 37535708 Free PMC article.
Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress.
Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG. Delfinis LJ, et al. Among authors: tsitkanou s. JCI Insight. 2022 Dec 22;7(24):e155147. doi: 10.1172/jci.insight.155147. JCI Insight. 2022. PMID: 36346680 Free PMC article.
14 results