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Metabolic alterations in fibroblasts of patients presenting with the MPAN subtype of neurodegeneration with brain iron accumulation (NBIA).
Wydrych A, Pakuła B, Jakubek-Olszewska P, Janikiewicz J, Dobosz AM, Cudna A, Rydzewski M, Pierzynowska K, Gaffke L, Cyske Z, Rintz E, Kurkowska-Jastrzębska I, Cwyl M, Pinton P, Węgrzyn G, Koopman WJH, Dobrzyń A, Skowrońska M, Lebiedzińska-Arciszewska M, Wieckowski MR. Wydrych A, et al. Among authors: dobrzyn a. Biochim Biophys Acta Mol Basis Dis. 2025 Jan;1871(1):167541. doi: 10.1016/j.bbadis.2024.167541. Epub 2024 Oct 15. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 39419454 Free article.
Metabolic impairments in neurodegeneration with brain iron accumulation.
Wydrych A, Pakuła B, Janikiewicz J, Dobosz AM, Jakubek-Olszewska P, Skowrońska M, Kurkowska-Jastrzębska I, Cwyl M, Popielarz M, Pinton P, Zavan B, Dobrzyń A, Lebiedzińska-Arciszewska M, Więckowski MR. Wydrych A, et al. Among authors: dobrzyn a. Biochim Biophys Acta Bioenerg. 2025 Jan 1;1866(1):149517. doi: 10.1016/j.bbabio.2024.149517. Epub 2024 Oct 2. Biochim Biophys Acta Bioenerg. 2025. PMID: 39366438 Free article. Review.
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency.
Cendrowski J, Wrobel M, Mazur M, Jary B, Maurya R, Wang S, Korostynski M, Dziewulska A, Rohm M, Kuropka P, Pudelko-Malik N, Mlynarz P, Dobrzyn A, Zeigerer A, Miaczynska M. Cendrowski J, et al. Among authors: dobrzyn a. Cell Mol Life Sci. 2024 Nov 19;81(1):458. doi: 10.1007/s00018-024-05490-y. Cell Mol Life Sci. 2024. PMID: 39560723 Free PMC article.
Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.
Dobosz AM, Janikiewicz J, Krogulec E, Dziewulska A, Ajduk A, Szpila M, Nieznańska H, Szczepankiewicz AA, Wypych D, Dobrzyn A. Dobosz AM, et al. Among authors: dobrzyn a. Mol Metab. 2023 Jan;67:101659. doi: 10.1016/j.molmet.2022.101659. Epub 2022 Dec 15. Mol Metab. 2023. PMID: 36529318 Free PMC article.
Diagnostic and therapeutic potential of protease inhibition.
Ćwilichowska N, Świderska KW, Dobrzyń A, Drąg M, Poręba M. Ćwilichowska N, et al. Among authors: dobrzyn a. Mol Aspects Med. 2022 Dec;88:101144. doi: 10.1016/j.mam.2022.101144. Epub 2022 Sep 26. Mol Aspects Med. 2022. PMID: 36174281 Free article. Review.
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.
Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, Simões RF, Karkucinska-Wieckowska A, Viegas I, Szymanska S, Dąbrowski M, Janikiewicz J, Cunha-Oliveira T, Dobrzyń A, Jones JG, Borges F, Wieckowski MR, Oliveira PJ. Amorim R, et al. Among authors: dobrzyn a. Redox Biol. 2022 Sep;55:102400. doi: 10.1016/j.redox.2022.102400. Epub 2022 Jul 16. Redox Biol. 2022. PMID: 35863265 Free PMC article.
96 results