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Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection.
Mukhiya R, Fleischmann WA, Loughland JR, Chan JA, de Labastida Rivera F, Andrew D, Beeson JG, McCarthy JS, Barber BE, Lopez JA, Engwerda C, Thomson-Luque R, Boyle MJ. Mukhiya R, et al. Among authors: chan ja. EBioMedicine. 2024 Nov;109:105419. doi: 10.1016/j.ebiom.2024.105419. Epub 2024 Oct 26. EBioMedicine. 2024. PMID: 39490199 Free PMC article.
Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.
Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ. Oyong DA, et al. Among authors: chan ja. EBioMedicine. 2022 Jan;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27. EBioMedicine. 2022. PMID: 34968760 Free PMC article.
Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains.
Feng G, Boyle MJ, Cross N, Chan JA, Reiling L, Osier F, Stanisic DI, Mueller I, Anders RF, McCarthy JS, Richards JS, Beeson JG. Feng G, et al. Among authors: chan ja. J Infect Dis. 2018 Jun 5;218(1):35-43. doi: 10.1093/infdis/jiy170. J Infect Dis. 2018. PMID: 29584918 Free PMC article. Clinical Trial.
Complement in malaria immunity and vaccines.
Kurtovic L, Boyle MJ, Opi DH, Kennedy AT, Tham WH, Reiling L, Chan JA, Beeson JG. Kurtovic L, et al. Among authors: chan ja. Immunol Rev. 2020 Jan;293(1):38-56. doi: 10.1111/imr.12802. Epub 2019 Sep 26. Immunol Rev. 2020. PMID: 31556468 Free PMC article. Review.
IgM in human immunity to Plasmodium falciparum malaria.
Boyle MJ, Chan JA, Handayuni I, Reiling L, Feng G, Hilton A, Kurtovic L, Oyong D, Piera KA, Barber BE, William T, Eisen DP, Minigo G, Langer C, Drew DR, de Labastida Rivera F, Amante FH, Williams TN, Kinyanjui S, Marsh K, Doolan DL, Engwerda C, Fowkes FJI, Grigg MJ, Mueller I, McCarthy JS, Anstey NM, Beeson JG. Boyle MJ, et al. Among authors: chan ja. Sci Adv. 2019 Sep 25;5(9):eaax4489. doi: 10.1126/sciadv.aax4489. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31579826 Free PMC article.
Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria.
Vijay R, Guthmiller JJ, Sturtz AJ, Surette FA, Rogers KJ, Sompallae RR, Li F, Pope RL, Chan JA, de Labastida Rivera F, Andrew D, Webb L, Maury WJ, Xue HH, Engwerda CR, McCarthy JS, Boyle MJ, Butler NS. Vijay R, et al. Among authors: chan ja. Nat Immunol. 2020 Jul;21(7):790-801. doi: 10.1038/s41590-020-0678-5. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424361 Free PMC article. Clinical Trial.
Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.
Webster R, Sekuloski S, Odedra A, Woolley S, Jennings H, Amante F, Trenholme KR, Healer J, Cowman AF, Eriksson EM, Sathe P, Penington J, Blanch AJ, Dixon MWA, Tilley L, Duffy MF, Craig A, Storm J, Chan JA, Evans K, Papenfuss AT, Schofield L, Griffin P, Barber BE, Andrew D, Boyle MJ, de Labastida Rivera F, Engwerda C, McCarthy JS. Webster R, et al. Among authors: chan ja. BMC Med. 2021 Nov 22;19(1):293. doi: 10.1186/s12916-021-02150-x. BMC Med. 2021. PMID: 34802442 Free PMC article. Clinical Trial.
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Chan JA, Loughland JR, de la Parte L, Okano S, Ssewanyana I, Nalubega M, Nankya F, Musinguzi K, Rek J, Arinaitwe E, Tipping P, Bourke P, Andrew D, Dooley N, SheelaNair A, Wines BD, Hogarth PM, Beeson JG, Greenhouse B, Dorsey G, Kamya M, Hartel G, Minigo G, Feeney M, Jagannathan P, Boyle MJ. Chan JA, et al. Nat Commun. 2022 Jul 18;13(1):4159. doi: 10.1038/s41467-022-31880-6. Nat Commun. 2022. PMID: 35851033 Free PMC article.
263 results