De Clercq E - Search Results

1

Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines.

Huang WJ, Pannecouque C, De Clercq E, Corona A, Maloccu S, Tramontano E, Wang S, Chen FE. Huang WJ, et al. Among authors: de clercq e. J Med Chem. 2024 Nov 14;67(21):19889-19904. doi: 10.1021/acs.jmedchem.4c02413. Epub 2024 Nov 5. J Med Chem. 2024. PMID: 39498544

2

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ji L, Chen FE, Xie B, De Clercq E, Balzarini J, Pannecouque C. Ji L, et al. Among authors: de clercq e. Eur J Med Chem. 2007 Feb;42(2):198-204. doi: 10.1016/j.ejmech.2006.09.018. Epub 2006 Nov 13. Eur J Med Chem. 2007. PMID: 17095124

3

Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

Ji L, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Ji L, et al. Among authors: de clercq e. J Med Chem. 2007 Apr 19;50(8):1778-86. doi: 10.1021/jm061167r. Epub 2007 Mar 24. J Med Chem. 2007. PMID: 17381078

4

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.

Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C. Xiong YZ, et al. Among authors: de clercq e. Eur J Med Chem. 2008 Jun;43(6):1230-6. doi: 10.1016/j.ejmech.2007.08.001. Epub 2007 Aug 11. Eur J Med Chem. 2008. PMID: 17869386

5

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Wang YP, et al. Among authors: de clercq e. Bioorg Med Chem. 2008 Apr 1;16(7):3887-94. doi: 10.1016/j.bmc.2008.01.039. Epub 2008 Jan 30. Bioorg Med Chem. 2008. PMID: 18267363

6

Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.

Wang YP, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Wang YP, et al. Among authors: de clercq e. Eur J Med Chem. 2009 Mar;44(3):1016-23. doi: 10.1016/j.ejmech.2008.06.028. Epub 2008 Jul 4. Eur J Med Chem. 2009. PMID: 18692274

7

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.

Feng XQ, Zeng ZS, Liang YH, Chen FE, Pannecouque C, Balzarini J, De Clercq E. Feng XQ, et al. Among authors: de clercq e. Bioorg Med Chem. 2010 Apr 1;18(7):2370-4. doi: 10.1016/j.bmc.2010.03.007. Epub 2010 Mar 9. Bioorg Med Chem. 2010. PMID: 20307984

8

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

Zeng ZS, He QQ, Liang YH, Feng XQ, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Zeng ZS, et al. Among authors: de clercq e. Bioorg Med Chem. 2010 Jul 15;18(14):5039-47. doi: 10.1016/j.bmc.2010.05.081. Epub 2010 Jun 4. Bioorg Med Chem. 2010. PMID: 20598556

9

Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.

Gu SX, He QQ, Yang SQ, Ma XD, Chen FE, De Clercq E, Balzarini J, Pannecouque C. Gu SX, et al. Among authors: de clercq e. Bioorg Med Chem. 2011 Sep 1;19(17):5117-24. doi: 10.1016/j.bmc.2011.07.023. Epub 2011 Jul 26. Bioorg Med Chem. 2011. PMID: 21824782

10

Dihydro-alkoxyl-benzyl-oxopyrimidine derivatives (DABOs) as non-nucleoside reverse transcriptase inhibitors: an update review (2001-2011).

Yang S, Chen FE, De Clercq E. Yang S, et al. Among authors: de clercq e. Curr Med Chem. 2012;19(2):152-62. doi: 10.2174/092986712803414169. Curr Med Chem. 2012. PMID: 22320294 Review.

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