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A 40-week phase 2B randomized, multicenter, double-blind, placebo-controlled study evaluating the safety and efficacy of memantine in amyotrophic lateral sclerosis.
Bhai S, Levine T, Moore D, Bowser R, Heim AJ, Walsh M, Shibani A, Simmons Z, Grogan J, Goyal NA, Govindarajan R, Hussain Y, Papsdorf T, Schwasinger-Schmidt T, Olney N, Goslin K, Pulley M, Kasarskis E, Weiss M, Katz SW, Moser S, Jabari D, Jawdat O, Statland J, Dimachkie MM, Barohn R; Neuromuscular Study Group and Western ALS Consortium Memantine ALS Study Group. Bhai S, et al. Among authors: simmons z. Muscle Nerve. 2025 Jan;71(1):63-72. doi: 10.1002/mus.28287. Epub 2024 Nov 7. Muscle Nerve. 2025. PMID: 39511965 Free PMC article. Clinical Trial.
Effects of mexiletine on hyperexcitability in sporadic amyotrophic lateral sclerosis: Preliminary findings from a small phase II randomized controlled trial.
Weiss MD, Macklin EA, McIlduff CE, Vucic S, Wainger BJ, Kiernan MC, Goutman SA, Goyal NA, Rutkove SB, Ladha SS, Chen IA, Harms MB, Brannagan TH, Lacomis D, Zivkovic S, Ma M, Wang LH, Simmons Z, Rivner MH, Shefner JM, Cudkowicz ME, Atassi N; Mexiletine-2 ALS Study Group. Weiss MD, et al. Among authors: simmons z. Muscle Nerve. 2021 Mar;63(3):371-383. doi: 10.1002/mus.27146. Epub 2020 Dec 31. Muscle Nerve. 2021. PMID: 33340120 Free PMC article. Clinical Trial.
Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.
Milligan C, Atassi N, Babu S, Barohn RJ, Caress JB, Cudkowicz ME, Evora A, Hawkins GA, Wosiski-Kuhn M, Macklin EA, Shefner JM, Simmons Z, Bowser RP, Ladha SS. Milligan C, et al. Among authors: simmons z. Muscle Nerve. 2021 Sep;64(3):309-320. doi: 10.1002/mus.27339. Epub 2021 Jun 24. Muscle Nerve. 2021. PMID: 34075589 Free PMC article. Clinical Trial.
Fixed dynamometry is more sensitive than vital capacity or ALS rating scale.
Andres PL, Allred MP, Stephens HE, Proffitt Bunnell M, Siener C, Macklin EA, Haines T, English RA, Fetterman KA, Kasarskis EJ, Florence J, Simmons Z, Cudkowicz ME. Andres PL, et al. Among authors: simmons z. Muscle Nerve. 2017 Oct;56(4):710-715. doi: 10.1002/mus.25586. Epub 2017 Mar 21. Muscle Nerve. 2017. PMID: 28120413
Primary lateral sclerosis (PLS) functional rating scale: PLS-specific clinimetric scale.
Mitsumoto H, Chiuzan C, Gilmore M, Zhang Y, Simmons Z, Paganoni S, Kisanuki YY, Zinman L, Jawdat O, Sorenson E, Floeter MK, Pioro EP, Fernandes Filho JAM, Heitzman D, Fournier CN, Oskarsson B, Heiman-Patterson T, Maragakis N, Joyce N, Hayat G, Nations S, Scelsa S, Walk D, Elman L, Hupf J, McHale B; PLSFRS study group. Mitsumoto H, et al. Among authors: simmons z. Muscle Nerve. 2020 Feb;61(2):163-172. doi: 10.1002/mus.26765. Epub 2019 Dec 13. Muscle Nerve. 2020. PMID: 31758557
Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities.
Andrews JA, Berry JD, Baloh RH, Carberry N, Cudkowicz ME, Dedi B, Glass J, Maragakis NJ, Miller TM, Paganoni S, Rothstein JD, Shefner JM, Simmons Z, Weiss MD, Bedlack RS. Andrews JA, et al. Among authors: simmons z. Muscle Nerve. 2020 Aug;62(2):182-186. doi: 10.1002/mus.26989. Epub 2020 Jun 5. Muscle Nerve. 2020. PMID: 32445195 Free PMC article.
262 results