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Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-h]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.
Gotchev D, Chen S, Dugan B, Dorsey BD, Wang X, Sheraz M, Kowalski R, Liu F, Tang S, Chiu T, Harasym T, Graves IE, Thi EP, Mason JD, Overholt N, Dugyala R, Lam AM, Cole AG, Sofia MJ. Gotchev D, et al. Among authors: dugyala r. J Med Chem. 2024 Nov 28;67(22):20467-20494. doi: 10.1021/acs.jmedchem.4c01928. Epub 2024 Nov 8. J Med Chem. 2024. PMID: 39513566
Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161.
Lam AM, Dugyala RR, Sheraz M, Liu F, Thi EP, Graves IE, Cuconati A, Steuer HM, Ardzinski A, Overholt N, Mason JD, Gotchev D, Cole AG, Harasym TO, Sofia MJ. Lam AM, et al. Among authors: dugyala rr. Viruses. 2024 Feb 21;16(3):323. doi: 10.3390/v16030323. Viruses. 2024. PMID: 38543689 Free PMC article.
Safety, immunogenicity and non-interference of concomitant Typhoid Vi capsular polysaccharide-tetanus toxoid conjugate vaccine (Typbar-TCV®) and measles or measles-mumps-rubella vaccines in 8-9 months-old Indian children.
Vadrevu KM, Dugyala R, Mahantashetti NS, Khalatkar V, Murthy K, Mogre S, Mitra M. Vadrevu KM, et al. Among authors: dugyala r. Hum Vaccin Immunother. 2022 Dec 30;18(7):2150030. doi: 10.1080/21645515.2022.2150030. Epub 2022 Dec 7. Hum Vaccin Immunother. 2022. PMID: 36476258 Free PMC article. Clinical Trial.
Evaluation of a standardised Vi poly-l-lysine ELISA for serology of Vi capsular polysaccharide antibodies.
Rigsby P, Beamish E, Hockley J, Atkinson E, Hitri K, Jones E, Yang JS, Qadri F, Bachtiar NS, Elias SC, Goel A, Mishra R, Dugyala R, Pasetti MF, Meiring JE, Mbewe M, Gordon MA, Pollard AJ, Logan A, Rijpkema S; anti-Vi IgG working group. Rigsby P, et al. Among authors: dugyala r. Biologicals. 2020 Jul;66:21-29. doi: 10.1016/j.biologicals.2020.05.002. Epub 2020 Jun 20. Biologicals. 2020. PMID: 32571662 Free PMC article.
17 results