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Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes.
Benafif S, Jones AB, Merson S, Rageevakumar R, McGrowder E, Tyler M, Cafferty F, Hogben M, Hussain N, Bancroft E, Reid A, Wakerell S, Karlsson Q, Saunders E, Whitmore I, Sorensen KD, Dennis N, Black E, Wood A, Richards K, Lees K, Perna C, Falconer A, Mills J, Hughes R, Kumar S, Mikropoulos C, Burnett S, Attard G, Hall E, Kote-Jarai Z, Eeles R. Benafif S, et al. Among authors: lees k. BJC Rep. 2024 Feb 15;2(1):15. doi: 10.1038/s44276-023-00024-8. BJC Rep. 2024. PMID: 39516637 Free PMC article.
Observation versus screening spinal MRI and pre-emptive treatment for spinal cord compression in patients with castration-resistant prostate cancer and spinal metastases in the UK (PROMPTS): an open-label, randomised, controlled, phase 3 trial.
Dearnaley D, Hinder V, Hijab A, Horan G, Srihari N, Rich P, Houston JG, Henry AM, Gibbs S, Venkitaraman R, Cruickshank C, Hassan S, Miners A, Mason M, Pedley I, Payne H, Brock S, Wade R, Robinson A, Din O, Lees K, Graham J, Worlding J, Murray J, Parker C, Griffin C, Sohaib A, Hall E; PROMPTS investigators. Dearnaley D, et al. Among authors: lees k. Lancet Oncol. 2022 Apr;23(4):501-513. doi: 10.1016/S1470-2045(22)00092-4. Epub 2022 Mar 10. Lancet Oncol. 2022. PMID: 35279270 Free PMC article. Clinical Trial.
Evaluating the impact of the metastatic spinal cord compression coordinator in a regional cancer network: a prospective, non-randomized pilot study.
Hakim RA, Galante JR, Zahid H, Karova M, Sirkis T, Ahmed Z, Taylor K, Dann S, Chae W, Tsirekidze A, Burcombe R, Moss C, Lees K, Adeleke S. Hakim RA, et al. Among authors: lees k. Ann Palliat Med. 2023 Jul;12(4):846-854. doi: 10.21037/apm-22-1102. Epub 2023 Apr 18. Ann Palliat Med. 2023. PMID: 37081702 Free article.
A Randomized, Double-Blind, Biomarker-Selected, Phase II Clinical Trial of Maintenance Poly ADP-Ribose Polymerase Inhibition With Rucaparib Following Chemotherapy for Metastatic Urothelial Carcinoma.
Crabb SJ, Hussain S, Soulis E, Hinsley S, Dempsey L, Trevethan A, Song Y, Barber J, Frew J, Gale J, Faust G, Brock S, McGovern U, Parikh O, Enting D, Sundar S, Ratnayake G, Lees K, Birtle AJ, Powles T, Jones RJ. Crabb SJ, et al. Among authors: lees k. J Clin Oncol. 2023 Jan 1;41(1):54-64. doi: 10.1200/JCO.22.00405. Epub 2022 Aug 12. J Clin Oncol. 2023. PMID: 35960902 Free PMC article. Clinical Trial.
Timing of radiotherapy after radical prostatectomy (RADICALS-RT): a randomised, controlled phase 3 trial.
Parker CC, Clarke NW, Cook AD, Kynaston HG, Petersen PM, Catton C, Cross W, Logue J, Parulekar W, Payne H, Persad R, Pickering H, Saad F, Anderson J, Bahl A, Bottomley D, Brasso K, Chahal R, Cooke PW, Eddy B, Gibbs S, Goh C, Gujral S, Heath C, Henderson A, Jaganathan R, Jakobsen H, James ND, Kanaga Sundaram S, Lees K, Lester J, Lindberg H, Money-Kyrle J, Morris S, O'Sullivan J, Ostler P, Owen L, Patel P, Pope A, Popert R, Raman R, Røder MA, Sayers I, Simms M, Wilson J, Zarkar A, Parmar MKB, Sydes MR. Parker CC, et al. Among authors: lees k. Lancet. 2020 Oct 31;396(10260):1413-1421. doi: 10.1016/S0140-6736(20)31553-1. Epub 2020 Sep 28. Lancet. 2020. PMID: 33002429 Free PMC article. Clinical Trial.
Normothermic ex vivo kidney perfusion preserves mitochondrial and graft function after warm ischemia and is further enhanced by AP39.
Kawamura M, Parmentier C, Ray S, Clotet-Freixas S, Leung S, John R, Mazilescu L, Nogueira E, Noguchi Y, Goto T, Arulratnam B, Ganesh S, Tamang T, Lees K, Reichman TW, Andreazza AC, Kim PK, Konvalinka A, Selzner M, Robinson LA. Kawamura M, et al. Among authors: lees k. Nat Commun. 2024 Sep 15;15(1):8086. doi: 10.1038/s41467-024-52140-9. Nat Commun. 2024. PMID: 39278958 Free PMC article.
676 results