Liang T - Search Results

1

Discovery of a Novel Macrocyclic Noncovalent CDK7 Inhibitor for Cancer Therapy.

Lu H, Zhang Y, Liu J, Jiang T, Yu X, Zhang H, Liang T, Peng J, Cai X, Lan X, Ren J, Ge M, Zhang J, Shang J, Yu J, Ren H, Liu Q, Gao J, Tang L, Ding X, Zhang M, Aliper A, Lu Q, Zhou F, Lan J, Ren F, Zhavoronkov A. Lu H, et al. Among authors: liang t. J Med Chem. 2024 Nov 28;67(22):20580-20594. doi: 10.1021/acs.jmedchem.4c02098. Epub 2024 Nov 9. J Med Chem. 2024. PMID: 39520367

2

Recent Development of Novel HDAC6 Isoform-selective Inhibitors.

Zhao Y, Liang T, Hou X, Fang H. Zhao Y, et al. Among authors: liang t. Curr Med Chem. 2021;28(21):4133-4151. doi: 10.2174/0929867327666201111142653. Curr Med Chem. 2021. PMID: 33176627 Review.

3

Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.

Liang T, Hou X, Zhou Y, Yang X, Fang H. Liang T, et al. ACS Med Chem Lett. 2019 Jul 5;10(8):1122-1127. doi: 10.1021/acsmedchemlett.9b00084. eCollection 2019 Aug 8. ACS Med Chem Lett. 2019. PMID: 31413795 Free PMC article.

4

Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.

Liang T, Xue J, Yao Z, Ye Y, Yang X, Hou X, Fang H. Liang T, et al. Eur J Med Chem. 2021 Oct 5;221:113526. doi: 10.1016/j.ejmech.2021.113526. Epub 2021 May 7. Eur J Med Chem. 2021. PMID: 33992929

5

Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity.

Liu M, Gao S, Liang T, Qiu X, Yang X, Fang H, Hou X. Liu M, et al. Among authors: liang t. J Med Chem. 2022 Sep 22;65(18):12200-12218. doi: 10.1021/acs.jmedchem.2c00866. Epub 2022 Sep 12. J Med Chem. 2022. PMID: 36097406

6

Structure, Functions and Selective Inhibitors of HDAC6.

Liang T, Fang H. Liang T, et al. Curr Top Med Chem. 2018;18(28):2429-2447. doi: 10.2174/1568026619666181129141822. Curr Top Med Chem. 2018. PMID: 30499393 Review.

7

Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma.

Zhou Y, Liu X, Xue J, Liu L, Liang T, Li W, Yang X, Hou X, Fang H. Zhou Y, et al. Among authors: liang t. J Med Chem. 2020 May 14;63(9):4701-4715. doi: 10.1021/acs.jmedchem.9b02161. Epub 2020 Apr 23. J Med Chem. 2020. PMID: 32267687

8

HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells.

Liang T, Zhou Y, Elhassan RM, Hou X, Yang X, Fang H. Liang T, et al. J Med Chem. 2020 Oct 22;63(20):12083-12099. doi: 10.1021/acs.jmedchem.0c01454. Epub 2020 Oct 6. J Med Chem. 2020. PMID: 33021789

9

Potential applications of BPFP1 in Bcl-2 protein quantification, carcinoma cell visualization, cell sorting and early cancer diagnosis.

Liang T, Li J, Zhou Y, Hou X, Yang X, Fang H. Liang T, et al. Eur J Med Chem. 2021 Nov 15;224:113725. doi: 10.1016/j.ejmech.2021.113725. Epub 2021 Aug 3. Eur J Med Chem. 2021. PMID: 34375882

10

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

Roecker AJ, Schirripa KM, Loughran HM, Tong L, Liang T, Fillgrove KL, Kuo Y, Bleasby K, Collier H, Altman MD, Ford MC, Drolet RE, Cosden M, Jinn S, Hatcher NG, Yao L, Kandebo M, Vardigan JD, Flick RB, Liu X, Minnick C, Price LA, Watt ML, Lemaire W, Burlein C, Adam GC, Austin LA, Marcus JN, Smith SM, Fraley ME. Roecker AJ, et al. Among authors: liang t. ACS Med Chem Lett. 2023 Jan 12;14(2):146-155. doi: 10.1021/acsmedchemlett.2c00441. eCollection 2023 Feb 9. ACS Med Chem Lett. 2023. PMID: 36793422 Free PMC article.

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