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How short peptides can disassemble ultra‐stable tau fibrils extracted from Alzheimer’s disease brain by a strain‐relief mechanism.
Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, Lutter L, Boyer D, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J, Eisenberg DS. Hou K, et al. Among authors: sawaya mr. Alzheimers Dement. 2025 Jan 9;20(Suppl 6):e085001. doi: 10.1002/alz.085001. eCollection 2024 Dec. Alzheimers Dement. 2025. PMID: 39782496 Free PMC article.
D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease.
Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, Mekkittikul M, Balbirnie M, Lantz C, Sawaya MR, Dolinsky JL, Jones M, Zuo X, Loo JA, Frautschy S, Cole G, Eisenberg DS. Hou K, et al. Among authors: sawaya mr. Sci Adv. 2024 May 3;10(18):eadl2991. doi: 10.1126/sciadv.adl2991. Epub 2024 May 1. Sci Adv. 2024. PMID: 38691615 Free PMC article.
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.
Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pękała M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L. Nguyen BA, et al. Among authors: sawaya mr. Nat Commun. 2024 Jan 17;15(1):581. doi: 10.1038/s41467-024-44820-3. Nat Commun. 2024. PMID: 38233397 Free PMC article.
243 results