Xia Q - Search Results

1

An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts.

He X, Xia Q, Bryant MS, Fu PP. He X, et al. Among authors: xia q. J Environ Sci Health C Toxicol Carcinog. 2024 Nov 15:1-16. doi: 10.1080/26896583.2024.2424091. Online ahead of print. J Environ Sci Health C Toxicol Carcinog. 2024. PMID: 39545694

2

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.

Xia Q, Yan J, Chou MW, Fu PP. Xia Q, et al. Toxicol Lett. 2008 May 5;178(2):77-82. doi: 10.1016/j.toxlet.2008.02.008. Epub 2008 Mar 4. Toxicol Lett. 2008. PMID: 18395999

3

Metabolic activation of pyrrolizidine alkaloids leading to phototoxicity and photogenotoxicity in human HaCaT keratinocytes.

Wang CC, Xia Q, Li M, Wang S, Zhao Y, Tolleson WH, Yin JJ, Fu PP. Wang CC, et al. Among authors: xia q. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(4):362-84. doi: 10.1080/10590501.2014.969980. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014. PMID: 25436474

4

7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids.

Xia Q, Ma L, He X, Cai L, Fu PP. Xia Q, et al. Chem Res Toxicol. 2015 Apr 20;28(4):615-20. doi: 10.1021/tx500417q. Epub 2015 Mar 31. Chem Res Toxicol. 2015. PMID: 25768656

5

7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids.

He X, Xia Q, Ma L, Fu PP. He X, et al. Among authors: xia q. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016;34(1):57-76. doi: 10.1080/10590501.2015.1135593. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016. PMID: 26761716

6

7-Glutathione-pyrrole and 7-cysteine-pyrrole are potential carcinogenic metabolites of pyrrolizidine alkaloids.

He X, Xia Q, Fu PP. He X, et al. Among authors: xia q. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017 Apr 3;35(2):69-83. doi: 10.1080/10590501.2017.1298358. Epub 2017 Mar 1. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017. PMID: 28418776

7

Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation.

Xia Q, He X, Ma L, Chen S, Fu PP. Xia Q, et al. Chem Res Toxicol. 2018 Jul 16;31(7):619-628. doi: 10.1021/acs.chemrestox.8b00096. Epub 2018 Jun 13. Chem Res Toxicol. 2018. PMID: 29855181

8

Primary and secondary pyrrolic metabolites of pyrrolizidine alkaloids form DNA adducts in human A549 cells.

He X, Xia Q, Wu Q, Tolleson WH, Lin G, Fu PP. He X, et al. Among authors: xia q. Toxicol In Vitro. 2019 Feb;54:286-294. doi: 10.1016/j.tiv.2018.10.009. Epub 2018 Oct 24. Toxicol In Vitro. 2019. PMID: 30366057

9

Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes.

He X, Xia Q, Shi Q, Fu PP. He X, et al. Among authors: xia q. J Environ Sci Health C Toxicol Carcinog. 2020;38(2):109-123. doi: 10.1080/26896583.2020.1738161. Epub 2020 Apr 27. J Environ Sci Health C Toxicol Carcinog. 2020. PMID: 32500832

10

Developing urinary pyrrole-amino acid adducts as non-invasive biomarkers for identifying pyrrolizidine alkaloids-induced liver injury in human.

Zhu L, Zhang C, Zhang W, Xia Q, Ma J, He X, He Y, Fu PP, Jia W, Zhuge Y, Lin G. Zhu L, et al. Among authors: xia q. Arch Toxicol. 2021 Oct;95(10):3191-3204. doi: 10.1007/s00204-021-03129-6. Epub 2021 Aug 14. Arch Toxicol. 2021. PMID: 34390356 Free PMC article.

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